(E)-Akt inhibitor-IV

Modify Date: 2024-01-12 19:29:04

(E)-Akt inhibitor-IV structure	Common Name	(E)-Akt inhibitor-IV
	CAS Number	959841-49-7	Molecular Weight	614.54200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₁H₂₇IN₄S	Melting Point	165-167 °C
	MSDS	N/A	Flash Point	N/A

Use of (E)-Akt inhibitor-IV

(E)-Akt inhibitor-IV ((E)-AKTIV) is a PI3K-Akt inhibitor, with potent cytotoxic[1].

Name	1H-Benzimidazolium, 6-(2-benzothiazolyl)-1-ethyl-2-[(1E)-2-(methylphenylamino)ethenyl]-3-phenyl-, iodide
Synonym	More Synonyms

Description	(E)-Akt inhibitor-IV ((E)-AKTIV) is a PI3K-Akt inhibitor, with potent cytotoxic[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target	Akt[1]
In Vitro	(E)-Akt inhibitor-IV (compound 7) exhibits average GI20 of 0.04 μM on four cell lines (MDA-MB468 cells, MDA-MB231 cells, MCF7 cells and 184B5 cells)[1]. (E)-Akt inhibitor-IV shows little effects on the growth of 184B5 non-cancer cells at the average GI20 doses[1].
References	[1]. Changkun Hu, et al. A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells. Eur J Med Chem. 2010 Feb;45(2):705-9.

Melting Point	165-167 °C
Molecular Formula	C₃₁H₂₇IN₄S
Molecular Weight	614.54200
Exact Mass	614.10000
PSA	53.18000
LogP	8.31990

AKT inhibitor IV

AKT INHIBITOR IV

DC Chemicals Limited
China
Product Name: (E)-Akt inhibitor-IV
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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