(E)-Akt inhibitor-IV

Modify Date: 2025-08-21 10:57:55

(E)-Akt inhibitor-IV Structure
(E)-Akt inhibitor-IV structure
 Common Name (E)-Akt inhibitor-IV
CAS Number 959841-49-7 Molecular Weight 614.54200
Density N/A Boiling Point N/A
Molecular Formula C31H27IN4S Melting Point 165-167 °C
MSDS N/A Flash Point N/A

 Use of (E)-Akt inhibitor-IV


(E)-Akt inhibitor-IV ((E)-AKTIV) is a PI3K-Akt inhibitor, with potent cytotoxic[1].

 Names

Name 1H-Benzimidazolium, 6-(2-benzothiazolyl)-1-ethyl-2-[(1E)-2-(methylphenylamino)ethenyl]-3-phenyl-, iodide
Synonym More Synonyms

 (E)-Akt inhibitor-IV Biological Activity

Description (E)-Akt inhibitor-IV ((E)-AKTIV) is a PI3K-Akt inhibitor, with potent cytotoxic[1].
Related Catalog
Target

Akt[1]

In Vitro (E)-Akt inhibitor-IV (compound 7) exhibits average GI20 of 0.04 μM on four cell lines (MDA-MB468 cells, MDA-MB231 cells, MCF7 cells and 184B5 cells)[1]. (E)-Akt inhibitor-IV shows little effects on the growth of 184B5 non-cancer cells at the average GI20 doses[1].
References

[1]. Changkun Hu, et al. A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells. Eur J Med Chem. 2010 Feb;45(2):705-9.

 Chemical & Physical Properties

Melting Point 165-167 °C
Molecular Formula C31H27IN4S
Molecular Weight 614.54200
Exact Mass 614.10000
PSA 53.18000
LogP 8.31990
InChIKey FIKDMAZMOIQHOO-ANVLNOONSA-N
SMILES CCN1c2cc(-c3nc4ccccc4s3)ccc2N(c2ccccc2)C1C=CN(C)c1ccccc1.I

 Synonyms

AKT inhibitor IV
AKT INHIBITOR IV
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