(E)-Akt inhibitor-IV

Names

[ CAS No. ]:
959841-49-7

[ Name ]:
(E)-Akt inhibitor-IV

[Synonym ]:
AKT inhibitor IV
AKT INHIBITOR IV

Biological Activity

[Description]:

(E)-Akt inhibitor-IV ((E)-AKTIV) is a PI3K-Akt inhibitor, with potent cytotoxic[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[Target]

Akt[1]

[In Vitro]

(E)-Akt inhibitor-IV (compound 7) exhibits average GI20 of 0.04 μM on four cell lines (MDA-MB468 cells, MDA-MB231 cells, MCF7 cells and 184B5 cells)[1]. (E)-Akt inhibitor-IV shows little effects on the growth of 184B5 non-cancer cells at the average GI20 doses[1].

[References]

[1]. Changkun Hu, et al. A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells. Eur J Med Chem. 2010 Feb;45(2):705-9.

Chemical & Physical Properties

[ Melting Point ]:
165-167 °C

[ Molecular Formula ]:
C₃₁H₂₇IN₄S

[ Molecular Weight ]:
614.54200

[ Exact Mass ]:
614.10000

[ PSA ]:
53.18000

[ LogP ]:
8.31990

(E)-Akt inhibitor-IV

Names

Biological Activity

Chemical & Physical Properties

Related Compounds