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β-Secretase Inhibitor IV

Names

[ CAS No. ]:
797035-11-1

[ Name ]:
β-Secretase Inhibitor IV

Biological Activity

[Description]:

β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Beta-secretase
Research Areas >> Neurological Disease

[Target]

IC50: 15.3±0.6 nM (BACE-1), 230±26 nM (BACE-2), 7620±210 nM (Cathepsin D)[1]


[In Vitro]

In the cell culture assay, β-Secretase Inhibitor IV (Compound 2) inhibits the production of Aβ peptides with an EC50 of 43 nM. β-Secretase Inhibitor IV potently suppresses the secretion of sAPP_NF and EV40 from HEK293T cells with an IC50 near 30 nM[1].

[References]

[1]. Pietrak BL, et al. Biochemical and cell-based assays for characterization of BACE-1 inhibitors. Anal Biochem. 2005 Jul 1;342(1):144-51.


[Related Small Molecules]

MK-8931 | LY2886721 | AZD3293(Lanabecestat) | LY2811376 | Epiberberine chloride | AZD3839 | LX-2343 | PF-06751979 | Sophoflavescenol | BACE-IN-1 | BACE1-IN-1

Chemical & Physical Properties

[ Molecular Formula ]:
C31H38N4O5S

[ Molecular Weight ]:
578.72

Related Compounds