797035-11-1
797035-11-1 structure
- Name: β-Secretase Inhibitor IV
- Chemical Name: BETA-SECRETASE INHIBITOR IV
- CAS Number: 797035-11-1
- Molecular Formula: C31H38N4O5S
- Molecular Weight: 578.72
- Catalog: Signaling Pathways Neuronal Signaling Beta-secretase
- Create Date: 2018-06-28 02:26:51
- Modify Date: 2024-01-05 16:09:34
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β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.
| Name | BETA-SECRETASE INHIBITOR IV |
|---|
| Description | β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively. |
|---|---|
| Related Catalog | |
| Target |
IC50: 15.3±0.6 nM (BACE-1), 230±26 nM (BACE-2), 7620±210 nM (Cathepsin D)[1] |
| In Vitro | In the cell culture assay, β-Secretase Inhibitor IV (Compound 2) inhibits the production of Aβ peptides with an EC50 of 43 nM. β-Secretase Inhibitor IV potently suppresses the secretion of sAPP_NF and EV40 from HEK293T cells with an IC50 near 30 nM[1]. |
| References |
| Molecular Formula | C31H38N4O5S |
|---|---|
| Molecular Weight | 578.72 |