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BACE1-IN-1

Names

[ CAS No. ]:
1310347-50-2

[ Name ]:
BACE1-IN-1

Biological Activity

[Description]:

BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Beta-secretase
Research Areas >> Neurological Disease

[Target]

IC50: 32 nM (human BACE1), 47 nM (human BACE2)[1]


[References]

[1]. Hilpert H, et al. β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J Med Chem. 2013 May 23;56(10):3980-95.


[Related Small Molecules]

MK-8931 | LY2886721 | AZD3293(Lanabecestat) | LY2811376 | Epiberberine chloride | AZD3839 | LX-2343 | PF-06751979 | Sophoflavescenol | BACE-IN-1 | β-Secretase Inhibitor IV

Chemical & Physical Properties

[ Molecular Formula ]:
C18H14F3N5O2

[ Molecular Weight ]:
389.33

[ Storage condition ]:
2-8℃

Related Compounds

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