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β-Secretase Inhibitor II

Names

[ CAS No. ]:
263563-09-3

[ Name ]:
β-Secretase Inhibitor II

Biological Activity

[Description]:

β-Secretase Inhibitor II is a β-Secretase inhibitor. β-Secretase Inhibitor II is a simple tripeptide aldehyde (IC50=700 nM for inhibition of total Aβ and IC50=2.5 μM for Aβ1–42). β-Secretase Inhibitor II can be used for the research of Alzheimer's disease[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Beta-secretase
Research Areas >> Neurological Disease

[Target]

IC50: 700 nM (Aβ)[1]. IC50: 2.5 μM (Aβ1–42)[1]


[In Vitro]

β-Secretase Inhibitor II is a simple tripeptide aldehyde (IC50=700 nM for inhibition of total Aβ and IC50=2.5 μM for Aβ1–42). β-Secretase Inhibitor II inhibits the formation of both total Aβ and Aβ1–42 in a dose-dependent manner[1].

[References]

[1]. Abbenante, G., et al. Inhibitors of β-Amyloid Formation Based on the β-Secretase Cleavage Site. Biochemical and Biophysical Research Communications. 2000; 268(1), 133–135.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H39N3O5

[ Molecular Weight ]:
461.59

Related Compounds