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MMP-2 Inhibitor II

Names

[ CAS No. ]:
869577-51-5

[ Name ]:
MMP-2 Inhibitor II

[Synonym ]:
Methanesulfonamide, N-[4-[4-[(oxiranylmethyl)sulfonyl]phenoxy]phenyl]-
N-(4-{4-[(2-Oxiranylmethyl)sulfonyl]phenoxy}phenyl)methanesulfonamide
MMP-2 Inhibitor II

Biological Activity

[Description]:

MMP-2 Inhibitor II (compound 2) is a selective MMP-2 inhibitor. The Kinetic parameters for MMP inhibition are 2.4 μM (MMP-2), 45 μM (MMP-1), and 379 μM (MMP-7), respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[Target]

MMP-1:45 μM (Ki)

MMP-2:2.4 μM (Ki)

MMP-7:379 μM (Ki)


[In Vitro]

基质金属蛋白酶 (Matrix metalloproteinases, MMPs) 是锌依赖性内肽酶，在生理病理条件下起重要作用[1]。

[References]

[1]. Ikejiri M, et al. Potent mechanism-based inhibitors for matrix metalloproteinases. J Biol Chem. 2005 Oct 7;280(40):33992-4002.  

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
591.7±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H17NO6S2

[ Molecular Weight ]:
383.439

[ Flash Point ]:
311.6±32.9 °C

[ Exact Mass ]:
383.049713

[ LogP ]:
2.24

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.624

Related Compounds