MMP Inhibitor II

Names

[ CAS No. ]:
203915-59-7

[ Name ]:
MMP Inhibitor II

[Synonym ]:
N25
2-Pyrimidinecarboxamide, hexahydro-N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-
N-Hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethylhexahydro-2-pyrimidinecarboxamide
1bqo
mmp inhibitor ii

Biological Activity

[Description]:

MMP Inhibitor II (compound 4e) is a potent, reversible pan-MMP inhibitor with IC50 values of 24 nM, 18.4 nM, 30 nM, and 2.7 nM for MMP-1,MMP-3, MMP-7, and MMP-9, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[Target]

MMP-1:24 nM (IC50)

MMP-3:18.4 nM (IC50)

MMP-7:30 nM (IC50)

MMP-9:2.7 nM (IC50)

[References]

[1]. S Pikul, et al. Discovery of potent, achiral matrix metalloproteinase inhibitors. J Med Chem. 1998 Sep 10;41(19):3568-71.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₂₁H₂₇N₃O₈S₂

[ Molecular Weight ]:
513.584

[ Exact Mass ]:
513.123962

[ PSA ]:
162.80000

[ LogP ]:
3.78

[ Index of Refraction ]:
1.591

Related Compounds

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