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GSK3β inhibitor II

Names

[ CAS No. ]:
478482-75-6

[ Name ]:
GSK3β inhibitor II

[Synonym ]:
GSK-3b Inhibitor II
Glycogen Synthase Kinase-3beta Inhibitor II
GSK-3 Inhibitor II
GSK-3beta Inhibitor II
2-(3-iodobenzylthio)-5-(pyridin-4-yl)-1,3,4-oxadiazole
2-thio(3-iodobenzyl)-5-(1-pyridyl)-[1,3,4]oxadiazole
HMS3229G14

Biological Activity

[Description]:

GSK3β inhibitor II is an inhibitor of GSK3β. GSK3β inhibitor II can be used for research of Alzheimer’s disease (AD)[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3
Research Areas >> Neurological Disease
Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[Target]

GSK-3β


[In Vitro]

GSK3β inhibitor II 与 Ile62、Phe67、Val70、Ala83 和 Leu188 具有疏水相互作用，与 Lys85 具有离子相互作用，以及与 Lys85 和 Val135 残基具有氢键相互作用[1]。 GSK3β inhibitor II 与 Val135[1] 形成氢键。

[References]

[1]. Elangovan ND, et al. Screening of potential drug for Alzheimer's disease: a computational study with GSK-3 β inhibition through virtual screening, docking, and molecular dynamics simulation. J Biomol Struct Dyn. 2021 Nov;39(18):7065-7079.  

Chemical & Physical Properties

[ Molecular Formula ]:
C14H10IN3OS

[ Molecular Weight ]:
395.21800

[ Exact Mass ]:
394.95900

[ PSA ]:
77.11000

[ LogP ]:
4.02850

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds