478482-75-6
478482-75-6 structure
- Name: GSK3β inhibitor II
- Chemical Name: 2-[(3-iodophenyl)methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole
- CAS Number: 478482-75-6
- Molecular Formula: C14H10IN3OS
- Molecular Weight: 395.21800
- Catalog: Signaling Pathways PI3K/Akt/mTOR GSK-3
- Create Date: 2017-03-26 18:13:45
- Modify Date: 2024-01-05 09:20:07
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GSK3β inhibitor II is an inhibitor of GSK3β. GSK3β inhibitor II can be used for research of Alzheimer’s disease (AD)[1].
| Name | 2-[(3-iodophenyl)methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole |
|---|---|
| Synonyms |
GSK-3b Inhibitor II
Glycogen Synthase Kinase-3beta Inhibitor II GSK-3 Inhibitor II GSK-3beta Inhibitor II 2-(3-iodobenzylthio)-5-(pyridin-4-yl)-1,3,4-oxadiazole 2-thio(3-iodobenzyl)-5-(1-pyridyl)-[1,3,4]oxadiazole HMS3229G14 |
| Description | GSK3β inhibitor II is an inhibitor of GSK3β. GSK3β inhibitor II can be used for research of Alzheimer’s disease (AD)[1]. |
|---|---|
| Related Catalog | |
| Target |
GSK-3β |
| In Vitro | GSK3β inhibitor II 与 Ile62、Phe67、Val70、Ala83 和 Leu188 具有疏水相互作用，与 Lys85 具有离子相互作用，以及与 Lys85 和 Val135 残基具有氢键相互作用[1]。 GSK3β inhibitor II 与 Val135[1] 形成氢键。 |
| References |
| Molecular Formula | C14H10IN3OS |
|---|---|
| Molecular Weight | 395.21800 |
| Exact Mass | 394.95900 |
| PSA | 77.11000 |
| LogP | 4.02850 |
|
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478482-75-6 |
| Literature: Lo Monte, Fabio; Kramer, Thomas; Gu, Jiamin; Anumala, Upendra Rao; Marinelli, Luciana; La Pietra, Valeria; Novellino, Ettore; Franco, Benedicte; Demedts, David; Van Leuven, Fred; Fuertes, Ana; Dominguez, Juan Manuel; Plotkin, Batya; Eldar-Finkelman, Hagit; Schmidt, Boris Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4407 - 4424 |
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478482-75-6 |
| Literature: Narum, Lars; Norskov-Lauritsen, Leif; Olesen, Preben H. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 11 p. 1525 - 1528 |
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478482-75-6 |
| Literature: Lo Monte, Fabio; Kramer, Thomas; Gu, Jiamin; Anumala, Upendra Rao; Marinelli, Luciana; La Pietra, Valeria; Novellino, Ettore; Franco, Benedicte; Demedts, David; Van Leuven, Fred; Fuertes, Ana; Dominguez, Juan Manuel; Plotkin, Batya; Eldar-Finkelman, Hagit; Schmidt, Boris Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4407 - 4424 |
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478482-75-6 |
| Literature: Lo Monte, Fabio; Kramer, Thomas; Gu, Jiamin; Anumala, Upendra Rao; Marinelli, Luciana; La Pietra, Valeria; Novellino, Ettore; Franco, Benedicte; Demedts, David; Van Leuven, Fred; Fuertes, Ana; Dominguez, Juan Manuel; Plotkin, Batya; Eldar-Finkelman, Hagit; Schmidt, Boris Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4407 - 4424 |
|
~%
478482-75-6 |
| Literature: Lo Monte, Fabio; Kramer, Thomas; Gu, Jiamin; Anumala, Upendra Rao; Marinelli, Luciana; La Pietra, Valeria; Novellino, Ettore; Franco, Benedicte; Demedts, David; Van Leuven, Fred; Fuertes, Ana; Dominguez, Juan Manuel; Plotkin, Batya; Eldar-Finkelman, Hagit; Schmidt, Boris Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4407 - 4424 |
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478482-75-6 |
| Literature: Lukas, Thomas J.; Schiltz, Gary E.; Arrat, Hasan; Scheidt, Karl; Siddique, Teepu Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 6 p. 1532 - 1537 |
| Precursor 6 | |
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| DownStream 0 | |