m-PEG2-O-Ph-NH2

Modify Date: 2024-01-10 08:51:28

m-PEG2-O-Ph-NH2 structure	Common Name	m-PEG2-O-Ph-NH2
	CAS Number	65673-48-5	Molecular Weight	211.25800
	Density	1.086g/cm3	Boiling Point	346.2ºC at 760 mmHg
	Molecular Formula	C₁₁H₁₇NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	173.9ºC

Use of m-PEG2-O-Ph-NH2

m-PEG2-O-Ph-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	4-[2-(2-methoxyethoxy)ethoxy]aniline
Synonym	More Synonyms

Description	m-PEG2-O-Ph-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density	1.086g/cm3
Boiling Point	346.2ºC at 760 mmHg
Molecular Formula	C₁₁H₁₇NO₃
Molecular Weight	211.25800
Flash Point	173.9ºC
Exact Mass	211.12100
PSA	53.71000
LogP	1.89180
Index of Refraction	1.52

N/A structure

N/A

CAS#:69828-74-6

~99%

m-PEG2-O-Ph-NH2 Structure

m-PEG2-O-Ph-NH2

CAS#:65673-48-5

Literature: Stein, Marco; Trauner, Dirk; Middendorp, Simon J.; Carta, Valentina; Sigel, Erwin; Pejo, Ervin; Raines, Douglas E.; Forman, Stuart A. Angewandte Chemie, International Edition, 2012 , vol. 51, # 42 p. 10500 - 10504,5 Angewandte Chemie, 2012 , vol. 124, # 42 p. 10652 - 10656,5 Title/Abstract Full Text Show Details Stein, Marco; Middendorp, Simon J.; Carta, Valentina; Pejo, Ervin; Raines, Douglas E.; Forman, Stuart A.; Sigel, Erwin; Trauner, Dirk Angewandte Chemie - International Edition, 2012 , vol. 51, # 42 p. 10500 - 10504 Angew. Chem., 2012 , vol. 124, # 42 p. 10652 - 10656,5

4-Nitrophenol structure

4-Nitrophenol

CAS#:100-02-7

~%

m-PEG2-O-Ph-NH2 Structure

m-PEG2-O-Ph-NH2

CAS#:65673-48-5

Literature: Chang, Kyoung-Jin; Kang, Byung-Nam; Lee, Min-Hee; Jeong, Kyu-Sung Journal of the American Chemical Society, 2005 , vol. 127, # 35 p. 12214 - 12215

m-PEG2-Tos structure

m-PEG2-Tos

CAS#:50586-80-6

~%

m-PEG2-O-Ph-NH2 Structure

m-PEG2-O-Ph-NH2

CAS#:65673-48-5

Literature: Chang, Kyoung-Jin; Kang, Byung-Nam; Lee, Min-Hee; Jeong, Kyu-Sung Journal of the American Chemical Society, 2005 , vol. 127, # 35 p. 12214 - 12215

m-PEG2-Br structure

m-PEG2-Br

CAS#:54149-17-6

~%

m-PEG2-O-Ph-NH2 Structure

m-PEG2-O-Ph-NH2

CAS#:65673-48-5

Literature: Stein, Marco; Trauner, Dirk; Middendorp, Simon J.; Carta, Valentina; Sigel, Erwin; Pejo, Ervin; Raines, Douglas E.; Forman, Stuart A. Angewandte Chemie, International Edition, 2012 , vol. 51, # 42 p. 10500 - 10504,5 Angewandte Chemie, 2012 , vol. 124, # 42 p. 10652 - 10656,5 Title/Abstract Full Text Show Details Stein, Marco; Middendorp, Simon J.; Carta, Valentina; Pejo, Ervin; Raines, Douglas E.; Forman, Stuart A.; Sigel, Erwin; Trauner, Dirk Angewandte Chemie - International Edition, 2012 , vol. 51, # 42 p. 10500 - 10504 Angew. Chem., 2012 , vol. 124, # 42 p. 10652 - 10656,5

Precursor 3
CAS#:100-02-7 4-Nitrophenol CAS#:50586-80-6 m-PEG2-Tos CAS#:54149-17-6 m-PEG2-Br
DownStream 0

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einecs 265-867-1

DC Chemicals Limited
China
Product Name: m-PEG2-O-Ph-NH2
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-(5-AMINO-2-METHOXYPHENYL)ACETAMIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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