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65673-48-5

65673-48-5 structure
65673-48-5 structure
  • Name: m-PEG2-O-Ph-NH2
  • Chemical Name: 4-[2-(2-methoxyethoxy)ethoxy]aniline
  • CAS Number: 65673-48-5
  • Molecular Formula: C11H17NO3
  • Molecular Weight: 211.25800
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-12-22 17:48:33
  • Modify Date: 2024-01-10 08:51:28
  • m-PEG2-O-Ph-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 4-[2-(2-methoxyethoxy)ethoxy]aniline
Synonyms iwxqvplyqqtjtr-uhfffaoysa
einecs 265-867-1
Description m-PEG2-O-Ph-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.086g/cm3
Boiling Point 346.2ºC at 760 mmHg
Molecular Formula C11H17NO3
Molecular Weight 211.25800
Flash Point 173.9ºC
Exact Mass 211.12100
PSA 53.71000
LogP 1.89180
Index of Refraction 1.52

~99%

65673-48-5 structure

65673-48-5

Literature: Stein, Marco; Trauner, Dirk; Middendorp, Simon J.; Carta, Valentina; Sigel, Erwin; Pejo, Ervin; Raines, Douglas E.; Forman, Stuart A. Angewandte Chemie, International Edition, 2012 , vol. 51, # 42 p. 10500 - 10504,5 Angewandte Chemie, 2012 , vol. 124, # 42 p. 10652 - 10656,5 Title/Abstract Full Text Show Details Stein, Marco; Middendorp, Simon J.; Carta, Valentina; Pejo, Ervin; Raines, Douglas E.; Forman, Stuart A.; Sigel, Erwin; Trauner, Dirk Angewandte Chemie - International Edition, 2012 , vol. 51, # 42 p. 10500 - 10504 Angew. Chem., 2012 , vol. 124, # 42 p. 10652 - 10656,5

~%

65673-48-5 structure

65673-48-5

Literature: Chang, Kyoung-Jin; Kang, Byung-Nam; Lee, Min-Hee; Jeong, Kyu-Sung Journal of the American Chemical Society, 2005 , vol. 127, # 35 p. 12214 - 12215

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65673-48-5 structure

65673-48-5

Literature: Chang, Kyoung-Jin; Kang, Byung-Nam; Lee, Min-Hee; Jeong, Kyu-Sung Journal of the American Chemical Society, 2005 , vol. 127, # 35 p. 12214 - 12215

~%

65673-48-5 structure

65673-48-5

Literature: Stein, Marco; Trauner, Dirk; Middendorp, Simon J.; Carta, Valentina; Sigel, Erwin; Pejo, Ervin; Raines, Douglas E.; Forman, Stuart A. Angewandte Chemie, International Edition, 2012 , vol. 51, # 42 p. 10500 - 10504,5 Angewandte Chemie, 2012 , vol. 124, # 42 p. 10652 - 10656,5 Title/Abstract Full Text Show Details Stein, Marco; Middendorp, Simon J.; Carta, Valentina; Pejo, Ervin; Raines, Douglas E.; Forman, Stuart A.; Sigel, Erwin; Trauner, Dirk Angewandte Chemie - International Edition, 2012 , vol. 51, # 42 p. 10500 - 10504 Angew. Chem., 2012 , vol. 124, # 42 p. 10652 - 10656,5
Precursor  3

DownStream  0