m-PEG2-phosphonic acid

Modify Date: 2024-01-12 18:51:42

m-PEG2-phosphonic acid Structure
m-PEG2-phosphonic acid structure
Common Name m-PEG2-phosphonic acid
CAS Number 96962-41-3 Molecular Weight 184.128
Density 1.3±0.1 g/cm3 Boiling Point 337.7±48.0 °C at 760 mmHg
Molecular Formula C5H13O5P Melting Point N/A
MSDS N/A Flash Point 158.0±29.6 °C

 Use of m-PEG2-phosphonic acid


m-PEG2-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name [2-(2-Methoxyethoxy)ethyl]phosphonic acid
Synonym More Synonyms

 m-PEG2-phosphonic acid Biological Activity

Description m-PEG2-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 337.7±48.0 °C at 760 mmHg
Molecular Formula C5H13O5P
Molecular Weight 184.128
Flash Point 158.0±29.6 °C
Exact Mass 184.050064
LogP -2.37
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.453

 Synonyms

[2-(2-Methoxyethoxy)ethyl]phosphonic acid
Phosphonic acid, [2-(2-methoxyethoxy)ethyl]-