m-PEG2-O-Ph-NH2

Names

[ CAS No. ]:
65673-48-5

[ Name ]:
m-PEG2-O-Ph-NH2

[Synonym ]:
iwxqvplyqqtjtr-uhfffaoysa
einecs 265-867-1

Biological Activity

[Description]:

m-PEG2-O-Ph-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.086g/cm3

[ Boiling Point ]:
346.2ºC at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₇NO₃

[ Molecular Weight ]:
211.25800

[ Flash Point ]:
173.9ºC

[ Exact Mass ]:
211.12100

[ PSA ]:
53.71000

[ LogP ]:
1.89180

[ Index of Refraction ]:
1.52

m-PEG2-O-Ph-NH2

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds