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m-PEG2-azide

Names

[ CAS No. ]:
215181-61-6

[ Name ]:
m-PEG2-azide

[Synonym ]:
Ethane, 1-azido-2-(2-methoxyethoxy)-
1-Azido-2-(2-methoxyethoxy)ethane
MFCD19672689
m-PEG2-Azide
Ethane, 1-(2-azidoethoxy)-2-methoxy-

Biological Activity

[Description]:

m-PEG2-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

Chemical & Physical Properties

[ Molecular Formula ]:
C5H11N3O2

[ Molecular Weight ]:
145.160

[ Exact Mass ]:
145.085129

[ LogP ]:
-0.15

Related Compounds