m-PEG2-Br

Names

[ Name ]:
m-PEG2-Br

[Synonym ]:
1-Bromo-(2-methoxyethoxy)ethane
1-Bromo-2-(2-methoxyethoxy)ethane
EINECS 259-000-6
MFCD00000238
1-(2-Bromoethoxy)-2-methoxyethane
Ethane, 1-bromo-2-(2-methoxyethoxy)-
Ethane, 1-(2-bromoethoxy)-2-methoxy-

Biological Activity

[Description]:

m-PEG2-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
184.4±15.0 °C at 760 mmHg

[ Molecular Formula ]:
C₅H₁₁BrO₂

[ Molecular Weight ]:
183.044

[ Flash Point ]:
73.9±0.0 °C

[ Exact Mass ]:
181.994232

[ PSA ]:
18.46000

[ LogP ]:
0.54

[ Vapour Pressure ]:
1.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.445

[ Storage condition ]:
Refrigerator (+4°C)

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S24/25

[ WGK Germany ]:
3

[ HS Code ]:
2909199090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2909199090

[ Summary ]:
2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Noncovalent polycationic coatings for capillaries in capillary electrophoresis of proteins.

Anal. Chem. 69(7) , 1370-9, (1997)

The adsorption of proteins with net positive charges (pI > pH) on the walls of fused-silica capillaries is a common problem in the analysis of proteins by capillary electrophoresis. This paper explore...

Molecular engineering of photoremovable protecting groups for two-photon uncaging.

Angew. Chem. Int. Ed. Engl. 47(49) , 9525-9, (2008)

Effect of charge density on energy-transfer properties of cationic conjugated polymers. Pu K-Y, et al.

Adv. Funct. Mater. 18(8) , 1321-1328