H-D-Phe-Pip-Arg-pNA

Modify Date: 2025-08-25 19:22:48

H-D-Phe-Pip-Arg-pNA structure	Common Name	H-D-Phe-Pip-Arg-pNA
	CAS Number	64815-81-2	Molecular Weight	552.62500
	Density	1.4g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₇H₃₆N₈O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of H-D-Phe-Pip-Arg-pNA

H-D-Phe-Pip-Arg-pNA, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA is sensitive, accurate, and easy to perform[1][2].

Name	(2S)-N-{(2S)-5-[(Diaminomethylene)amino]-1-[(4-nitrophenyl)amino] -1-oxo-2-pentanyl}-1-(D-phenylalanyl)-2-piperidinecarboxamide

Description	H-D-Phe-Pip-Arg-pNA, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA is sensitive, accurate, and easy to perform[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Goodnight SH Jr, et al. Measurement of antithrombin III in normal and pathologic states using chromogenic substrate S-2238. Comparison with immunoelectrophoretic and factor Xa inhibition assays. Am J Clin Pathol. 1980;73(5):639-647. [2]. Voorthuizen H, Kluft C. Improved assay conditions for automated antithrombin III determinations with the chromogenic substrate S-2238. Thromb Haemost. 1984;52(3):350-353.

Description

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. Goodnight SH Jr, et al. Measurement of antithrombin III in normal and pathologic states using chromogenic substrate S-2238. Comparison with immunoelectrophoretic and factor Xa inhibition assays. Am J Clin Pathol. 1980;73(5):639-647.

[2]. Voorthuizen H, Kluft C. Improved assay conditions for automated antithrombin III determinations with the chromogenic substrate S-2238. Thromb Haemost. 1984;52(3):350-353.