H-D-Phe-Pip-Arg-pNA dihydrochloride

Modify Date: 2024-01-04 21:40:29

H-D-Phe-Pip-Arg-pNA dihydrochloride Structure
H-D-Phe-Pip-Arg-pNA dihydrochloride structure
Common Name H-D-Phe-Pip-Arg-pNA dihydrochloride
CAS Number 62354-65-8 Molecular Weight 625.55
Density N/A Boiling Point N/A
Molecular Formula C27H38Cl2N8O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of H-D-Phe-Pip-Arg-pNA dihydrochloride


H-D-Phe-Pip-Arg-pNA (S-2238) dihydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA dihydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA dihydrochloride is sensitive, accurate, and easy to perform[1][2].

 Names

Name H-D-Phe-Pip-Arg-pNA dihydrochloride

 H-D-Phe-Pip-Arg-pNA dihydrochloride Biological Activity

Description H-D-Phe-Pip-Arg-pNA (S-2238) dihydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA dihydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA dihydrochloride is sensitive, accurate, and easy to perform[1][2].
Related Catalog
References

[1]. Goodnight SH Jr, et al. Measurement of antithrombin III in normal and pathologic states using chromogenic substrate S-2238. Comparison with immunoelectrophoretic and factor Xa inhibition assays. Am J Clin Pathol. 1980;73(5):639-647.

[2]. Voorthuizen H, Kluft C. Improved assay conditions for automated antithrombin III determinations with the chromogenic substrate S-2238. Thromb Haemost. 1984;52(3):350-353.

 Chemical & Physical Properties

Molecular Formula C27H38Cl2N8O5
Molecular Weight 625.55