H-D-Phe-Pip-Arg-pNA hydrochloride

Modify Date: 2025-08-29 21:20:38

H-D-Phe-Pip-Arg-pNA hydrochloride Structure
H-D-Phe-Pip-Arg-pNA hydrochloride structure
 Common Name H-D-Phe-Pip-Arg-pNA hydrochloride
CAS Number 160192-34-7 Molecular Weight 589.09
Density N/A Boiling Point N/A
Molecular Formula C27H37ClN8O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of H-D-Phe-Pip-Arg-pNA hydrochloride


H-D-Phe-Pip-Arg-pNA hydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA hydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA hydrochloride is sensitive, accurate, and easy to perform[1][2].

 Names

Name H-D-Phe-Pip-Arg-pNA hydrochloride

 H-D-Phe-Pip-Arg-pNA hydrochloride Biological Activity

Description H-D-Phe-Pip-Arg-pNA hydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA hydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA hydrochloride is sensitive, accurate, and easy to perform[1][2].
Related Catalog
References

[1]. Goodnight SH Jr, et al. Measurement of antithrombin III in normal and pathologic states using chromogenic substrate S-2238. Comparison with immunoelectrophoretic and factor Xa inhibition assays. Am J Clin Pathol. 1980;73(5):639-647.

[2]. van Voorthuizen H, Kluft C. Improved assay conditions for automated antithrombin III determinations with the chromogenic substrate S-2238. Thromb Haemost. 1984;52(3):350-353.

 Chemical & Physical Properties

Molecular Formula C27H37ClN8O5
Molecular Weight 589.09
InChIKey YEOVJZRYPLLHJL-FMVQVTEISA-N
SMILES Cl.NC(N)=NCCCC(NC(=O)C1CCCCN1C(=O)C(N)Cc1ccccc1)C(=O)Nc1ccc([N+](=O)[O-])cc1
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