74392-49-7

74392-49-7 structure

Name: H-D-Phe-Phe-Arg-chloromethylketone trifluoroacetate salt
Chemical Name: H-D-Phe-Phe-Arg-chloromethylketone
CAS Number: 74392-49-7
Molecular Formula: C₂₅H₃₃ClN₆O₃
Molecular Weight: 501.02100
Catalog: Signaling Pathways Metabolic Enzyme/Protease Ser/Thr Protease
Create Date: 2018-12-23 18:39:51
Modify Date: 2025-08-24 18:15:46
PPACK II is an irreversible and specific glandular and plasma kallikreins inhibitor[1].

Name	H-D-Phe-Phe-Arg-chloromethylketone
Synonyms	phenylalanyl-phenylalanyl-argininechloromethylketone D-Phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-L-phenylalaninamide H-D-PHE-PHE-ARG-CMK TFA DPHE-PHE-ARG-CHLOROMETHYLKETONE D-Phe-Phe-Arg Chloromethylketone Trifluoroacetate Salt H-D-PHE-PHE-ARG-CHLOROMETHYLKETONE TRIFLUOROACETATE SALT DPHE-PHE-ARG-CMK PPACK II,TRIFLUOROACETATE SALT

Description	PPACK II is an irreversible and specific glandular and plasma kallikreins inhibitor[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cardiovascular Disease
In Vitro	PPACK II (0.62-50 μg/mL) 显着抑制 B 型钠尿肽 (BNP) 蛋白水解[2]。
References	[1]. Kentaro Takayama, et al. Identification of a degrading enzyme in human serum that hydrolyzes a C-terminal core sequence of neuromedin U. Biopolymers. 2016 Nov 4;106(4):440-5. [2]. Alexander Belenky, et al. The effect of class-specific protease inhibitors on the stabilization of B-type natriuretic peptide in human plasma. Clin Chim Acta. 2004 Feb;340(1-2):163-72.