Tetrahydroberberine

Modify Date: 2025-08-21 17:35:26

Tetrahydroberberine structure	Common Name	Tetrahydroberberine
	CAS Number	522-97-4	Molecular Weight	339.385
	Density	1.3±0.1 g/cm3	Boiling Point	476.1±45.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₁NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	141.1±25.9 °C

Use of Tetrahydroberberine

Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber; has micromolar affinity for dopamine D(2) (pK(i) = 6.08) and 5-HT(1A) (pK(i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors (5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK(i) < 5.00).

Name	canadine
Synonym	More Synonyms

Description	Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber; has micromolar affinity for dopamine D(2) (pK(i) = 6.08) and 5-HT(1A) (pK(i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors (5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK(i) < 5.00).
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Natural Products >> Alkaloid Research Areas >> Neurological Disease
References	[1]. Lee TH, et al. Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function. J Pharmacol Exp Ther. 2011 Sep;338(3):917-24. [2]. Niwa M, et al. Dopaminergic unique affinity of tetrahydroberberine and l-tetrahydroberberine-d-camphor sulfonate. Pharmacology. 1991;43(6):329-36.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Natural Products >> Alkaloid

Research Areas >> Neurological Disease

References

[1]. Lee TH, et al. Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function. J Pharmacol Exp Ther. 2011 Sep;338(3):917-24.

[2]. Niwa M, et al. Dopaminergic unique affinity of tetrahydroberberine and l-tetrahydroberberine-d-camphor sulfonate. Pharmacology. 1991;43(6):329-36.

Density	1.3±0.1 g/cm3
Boiling Point	476.1±45.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₁NO₄
Molecular Weight	339.385
Flash Point	141.1±25.9 °C
Exact Mass	339.147064
PSA	40.16000
LogP	3.83
Appearance of Characters	solid \| yellow
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.656
InChIKey	VZTUIEROBZXUFA-UHFFFAOYSA-N
SMILES	COc1ccc2c(c1OC)CN1CCc3cc4c(cc3C1C2)OCO4
Storage condition	2-8°C
Water Solubility	DMSO: >10 mg/mL, soluble

Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	36
WGK Germany	3

Precursor 4
CAS#:50-00-0 Formaldehyde CAS#:74203-90-0 (-)-canadine HCl CAS#:29074-38-2 6H-Benzo[g]-1,3... CAS#:1356336-75-8 (1S)-1-[3,4-dim...
DownStream 6
CAS#:483-15-8 Dihydroberberine CAS#:4263-84-7 Benzo(g)-1,3-be... CAS#:6880-91-7 Dihydrochelerythrine CAS#:485-91-6 Allocryptopine
CAS#:10134-52-8 Berberinol CAS#:47474-49-7 (S)-N-methylcanadine

l-Xanthopuccine

Hydroberberine

6H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine, 5,8,13,13a-tetrahydro-9,10-dimethoxy-

9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline

9,10-Dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline

canadine

Tetrahydroberberine,THB

l-Canadine

(±)-Canadine

EINECS 208-338-2

5,6,13,13a-Tetrahydro-9,10-dimethoxy-2,3-(methylenedioxy)-8H-dibenzo[a,g]quinolizine

MFCD00067284

6H-1,3-Benzodioxolo[5,6-a]benzo[g]quinolizine, 5,8,13,13a-tetrahydro-9,10-dimethoxy-

dl-Canadine

UNII:V2SSH085X8

l-Tetrahydroberberine

5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine

THB

Tetrahydroberberine

5,6,13,13a-Tetrahydro-9,10-dimethoxy-2,3-(methylenedioxy)-8H-dibenzo(a,g)quinolizine

dl-Tetrahydroberberine

9,10-bis(methyloxy)-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline

xanthopuccine

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Tetrahydroberberine
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Tetrahydroberberine
Price: ￥398.0/20mg
Purity: 98.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Tetrahydroberberine
Price: $280.0/20mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Canadine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Get all suppliers and price by the below link:

Tetrahydroberberine suppliers

Price: $106/10mM*1mLinDMSO

Reference only. check more Tetrahydroberberine price

Tetrahydroberberine

Use of Tetrahydroberberine

Names

Tetrahydroberberine Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Precursor & DownStream

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.