Dihydrochelerythrine

Modify Date: 2024-01-02 16:48:35

Dihydrochelerythrine structure	Common Name	Dihydrochelerythrine
	CAS Number	6880-91-7	Molecular Weight	349.380
	Density	1.3±0.1 g/cm3	Boiling Point	565.9±50.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₁₉NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	171.6±27.3 °C

Use of Dihydrochelerythrine

Dihydrochelerythrine is a natural compound isolated from the leaves of Macleaya microcarpa; has antifungal activity.IC50 value:Target: in vitro: Dihydrochelerythrine showed the highest antifungal activity against B. cinerea Pers, with 98.32% mycelial growth inhibition at 50 μg/mL. Dihydrochelerythrine inhibited spore germination in vitro in a concentration-dependent manner [1]. Dihydrochelerythrine appeared to be less cytotoxic since the viability of cells exposed to 20 microM dihydrochelerythrine for 24h was reduced only to 53%. A dose-dependent induction of apoptosis and necrosis by chelerythrine and dihydrochelerythrine was confirmed by annexin V/propidium iodide dual staining flow cytometry [2]. Dihydrochelerythrine (4) exhibited strong activity against methicillin-resistant Staphylococcus aureus SK1 and moderate activity against Escherichia coli TISTR 780 with MIC values of 8 and 16 μg/mL, respectively [3].

Name	1,2-dimethoxy-12-methyl-13H-[1,3]benzodioxolo[5,6-c]phenanthridine
Synonym	More Synonyms

Description	Dihydrochelerythrine is a natural compound isolated from the leaves of Macleaya microcarpa; has antifungal activity.IC50 value:Target: in vitro: Dihydrochelerythrine showed the highest antifungal activity against B. cinerea Pers, with 98.32% mycelial growth inhibition at 50 μg/mL. Dihydrochelerythrine inhibited spore germination in vitro in a concentration-dependent manner [1]. Dihydrochelerythrine appeared to be less cytotoxic since the viability of cells exposed to 20 microM dihydrochelerythrine for 24h was reduced only to 53%. A dose-dependent induction of apoptosis and necrosis by chelerythrine and dihydrochelerythrine was confirmed by annexin V/propidium iodide dual staining flow cytometry [2]. Dihydrochelerythrine (4) exhibited strong activity against methicillin-resistant Staphylococcus aureus SK1 and moderate activity against Escherichia coli TISTR 780 with MIC values of 8 and 16 μg/mL, respectively [3].
Related Catalog	Signaling Pathways >> Anti-infection >> Fungal Natural Products >> Alkaloid Research Areas >> Infection
References	[1]. Feng G, et al. Inhibitory activity of dihydrosanguinarine and dihydrochelerythrine against phytopathogenic fungi. Nat Prod Res. 2011 Jul;25(11):1082-9. [2]. Vrba J, et al. Chelerythrine and dihydrochelerythrine induce G1 phase arrest and bimodal cell death in human leukemia HL-60 cells. Toxicol In Vitro. 2008 Jun;22(4):1008-17. [3]. Tantapakul C, et al. Antibacterial compounds from Zanthoxylum rhetsa. Arch Pharm Res. 2012 Jul;35(7):1139-42.

Description

Related Catalog

Signaling Pathways >> Anti-infection >> Fungal

Natural Products >> Alkaloid

Research Areas >> Infection

References

[1]. Feng G, et al. Inhibitory activity of dihydrosanguinarine and dihydrochelerythrine against phytopathogenic fungi. Nat Prod Res. 2011 Jul;25(11):1082-9.

[2]. Vrba J, et al. Chelerythrine and dihydrochelerythrine induce G1 phase arrest and bimodal cell death in human leukemia HL-60 cells. Toxicol In Vitro. 2008 Jun;22(4):1008-17.

[3]. Tantapakul C, et al. Antibacterial compounds from Zanthoxylum rhetsa. Arch Pharm Res. 2012 Jul;35(7):1139-42.

Density	1.3±0.1 g/cm3
Boiling Point	565.9±50.0 °C at 760 mmHg
Molecular Formula	C₂₁H₁₉NO₄
Molecular Weight	349.380
Flash Point	171.6±27.3 °C
Exact Mass	349.131409
PSA	40.16000
LogP	4.56
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.657
Storage condition	2-8℃

HS Code	2933990090

Precursor 9
CAS#:64-18-6 Formic Acid CAS#:6900-99-8 Norchelerythrine CAS#:485-91-6 Allocryptopine CAS#:34316-15-9 Chelerythrine
CAS#:77-78-1 Dimethyl sulfate CAS#:610788-51-7 N-(6-bromo-2,3-... CAS#:3895-92-9 Chelerythrine c... CAS#:72584-80-6 11,11-diacetoxy...
CAS#:67258-01-9 4b,10bβ,11,12-t...
DownStream 2
CAS#:3895-92-9 Chelerythrine c... CAS#:28342-33-8 6-Oxochelerythrine

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

bocconoline

[1,3]Benzodioxolo[5,6-c]phenanthridine, 12,13-dihydro-1,2-dimethoxy-12-methyl-

Dihydrochelerythrine

(1,3)Benzodioxolo(5,6-c)phenanthridine, 12,13-dihydro-1,2-dimethoxy-12-methyl-

5,6-dihydrochelerythrine

12,13-dihydrochelerythrine

1,2-Dimethoxy-12-methyl-12,13-dihydro[1,3]benzodioxolo[5,6-c]phenanthridine

BioBioPha
China
Product Name: Dihydrochelerythrine
Price: ￥Inquiry/10mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Dihydrochelerythrine
Price: ￥4000.0/5mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Dihydrochelerythrine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Dihydrochelerythrine
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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Dihydrochelerythrine

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