Dihydroberberine

Modify Date: 2024-01-02 20:07:09

Dihydroberberine Structure
Dihydroberberine structure
Common Name Dihydroberberine
CAS Number 483-15-8 Molecular Weight 337.369
Density 1.4±0.1 g/cm3 Boiling Point 557.8±50.0 °C at 760 mmHg
Molecular Formula C20H19NO4 Melting Point 223-224ºC (dec.)
MSDS N/A Flash Point 170.7±27.3 °C

 Use of Dihydroberberine


Dihydroberberine inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces heat shock protein 90 (Hsp90) expression and its interaction with hERG. Dihydroberberine has anti-inflammatory, anti-atherosclerotic, hypolipidemic and antitumor activities[1].

 Names

Name 9,10-Dimethoxy-6,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline
Synonym More Synonyms

 Dihydroberberine Biological Activity

Description Dihydroberberine inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces heat shock protein 90 (Hsp90) expression and its interaction with hERG. Dihydroberberine has anti-inflammatory, anti-atherosclerotic, hypolipidemic and antitumor activities[1].
Related Catalog
Target

HSP90

References

[1]. Yu D, et al. Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells. PLoS One. 2017 Aug 1;12(8):e0181823.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 557.8±50.0 °C at 760 mmHg
Melting Point 223-224ºC (dec.)
Molecular Formula C20H19NO4
Molecular Weight 337.369
Flash Point 170.7±27.3 °C
Exact Mass 337.131409
PSA 40.16000
LogP 5.09
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.679
Storage condition 2-8C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DR9808500
CHEMICAL NAME :
Berbine, 13,13a-didehydro-9,10-dimethoxy-2,3-(methylenedioxy)-
CAS REGISTRY NUMBER :
483-15-8
BEILSTEIN REFERENCE NO. :
0344128
LAST UPDATED :
199709
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H19-N-O4
MOLECULAR WEIGHT :
337.40
WISWESSER LINE NOTATION :
T G6 E6 B665 EN SO UO FH TH&&T&&J HO1 IO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
190 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 15,486,1981

 Safety Information

HS Code 2934999090

 Synthetic Route

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

9,10-Dimethoxy-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline
Dihydroberbine
6H-1,3-Benzodioxolo[5,6-a]benzo[g]quinolizine, 5,8-dihydro-9,10-dimethoxy-
9,10-Dimethoxy-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline
Dihydroberberine
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