Dihydroberberine

Modify Date: 2025-08-20 22:33:45

Dihydroberberine structure	Common Name	Dihydroberberine
	CAS Number	483-15-8	Molecular Weight	337.369
	Density	1.4±0.1 g/cm3	Boiling Point	557.8±50.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₁₉NO₄	Melting Point	223-224ºC (dec.)
	MSDS	N/A	Flash Point	170.7±27.3 °C

Use of Dihydroberberine

Dihydroberberine inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces heat shock protein 90 (Hsp90) expression and its interaction with hERG. Dihydroberberine has anti-inflammatory, anti-atherosclerotic, hypolipidemic and antitumor activities[1].

Name	9,10-Dimethoxy-6,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline
Synonym	More Synonyms

Description	Dihydroberberine inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces heat shock protein 90 (Hsp90) expression and its interaction with hERG. Dihydroberberine has anti-inflammatory, anti-atherosclerotic, hypolipidemic and antitumor activities[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Research Areas >> Inflammation/Immunology Signaling Pathways >> Cell Cycle/DNA Damage >> HSP Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	HSP90
References	[1]. Yu D, et al. Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells. PLoS One. 2017 Aug 1;12(8):e0181823.

Density	1.4±0.1 g/cm3
Boiling Point	557.8±50.0 °C at 760 mmHg
Melting Point	223-224ºC (dec.)
Molecular Formula	C₂₀H₁₉NO₄
Molecular Weight	337.369
Flash Point	170.7±27.3 °C
Exact Mass	337.131409
PSA	40.16000
LogP	5.09
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.679
Storage condition	2-8C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DR9808500

CHEMICAL NAME :: Berbine, 13,13a-didehydro-9,10-dimethoxy-2,3-(methylenedioxy)-

CAS REGISTRY NUMBER :: 483-15-8

BEILSTEIN REFERENCE NO. :: 0344128

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H19-N-O4

MOLECULAR WEIGHT :: 337.40

WISWESSER LINE NOTATION :: T G6 E6 B665 EN SO UO FH TH&&T&&J HO1 IO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 190 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 15,486,1981

HS Code	2934999090

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