Diethyl ether

Diethyl ether Structure
Diethyl ether
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Common Name Diethyl ether
CAS Number 60-29-7 Molecular Weight 74.122
Density 0.7±0.1 g/cm3 Boiling Point 33.2±3.0 °C at 760 mmHg
Molecular Formula C4H10O Melting Point -116 °C
MSDSDiethyl ether MSDS|SDS|pdf download Chinese USA Flash Point -40.0±0.0 °C
Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger

Controlled Substances:Psychoactive Drugs/Narcotic Drugs/Hypertoxic Chemicals/Non-Medical Use of Narcotic Drugs and Psychotropic Substances


 Names

[ Name ]: Diethyl ether
[ Synonym ]: More Synonyms

 Chemical & Physical Properties

[ Density ]: 0.7±0.1 g/cm3
[ Boiling Point ]: 33.2±3.0 °C at 760 mmHg
[ Melting Point ]: -116 °C
[ Molecular Formula ]: C4H10O
[ Molecular Weight ]: 74.122
[ Flash Point ]: -40.0±0.0 °C
[ Exact Mass ]: 74.073166
[ PSA ]: 9.23000
[ LogP ]: 0.98
[ Vapour density ]: 2.6 (vs air)
[ Vapour Pressure ]: 566.8±0.1 mmHg at 25°C
[ Index of Refraction ]: 1.361
[ Storage condition ]: Store at RT.
[ Water Solubility ]: 69 g/L (20 ºC)
[ Freezing Point ]: -116.3℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KI5775000
CHEMICAL NAME :
Ethane, 1,1'-oxybis-
CAS REGISTRY NUMBER :
60-29-7
LAST UPDATED :
199712
DATA ITEMS CITED :
59
MOLECULAR FORMULA :
C4-H10-O
MOLECULAR WEIGHT :
74.14
WISWESSER LINE NOTATION :
2O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Human
TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
260 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human
DOSE/DURATION :
200 ppm
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1215 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
32000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
31000 ppm/30M
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2420 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
996 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
76000 ppm
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
106000 ppm
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>20 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
24 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1000 ppm/24H/5W-C
TOXIC EFFECTS :
Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1 pph/24H/5W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Rodent - hamster Fibroblast
DOSE/DURATION :
1 pph
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year: 43,21,1975 *** REVIEWS *** ACGIH TLV-STEL 1520 mg/m3 (500 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 1210 mg/m3 (400 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal No Adequate Data IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,93,1987 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 400 ppm (1200 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,106,1971 OSHA PEL (Gen Indu):8H TWA 400 ppm (1200 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 400 ppm (1200 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 400 ppm (1200 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 400 ppm (1200 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 400 ppm (1200 mg/m3);STEL 500 ppm (1500 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 400 ppm (1200 mg/m3) JAN 1993 OEL-BELGIUM:TWA 400 ppm (1210 mg/m3);STEL 500 ppm (1520 mg/m3) JAN 1993 OEL-DENMARK:TWA 400 ppm (1200 mg/m3) JAN 1993 OEL-FINLAND:TWA 400 ppm (1200 mg/m3);STEL 500 ppm (1500 mg/m3) JAN 1993 OEL-FRANCE:TWA 400 ppm (1200 mg/m3);STEL 500 ppm (1500 mg/m3) JAN 1993 OEL-GERMANY:TWA 400 ppm (1200 mg/m3) JAN 1993 OEL-HUNGARY:TWA 300 mg/m3;STEL 600 mg/m3;Skin JAN 1993 OEL-JAPAN:TWA 400 ppm (1200 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 400 ppm (1200 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 400 ppm (1200 mg/m3) JAN 1993 OEL-POLAND:TWA 300 mg/m3 JAN 1993 OEL-RUSSIA:TWA 400 ppm;STEL 300 mg/m3 JAN 1993 OEL-SWEDEN:TWA 400 ppm (1200 mg/m3);STEL 500 ppm (1500 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 400 ppm (1200 mg/m3);STEL 800 ppm JAN 1993 OEL-TURKEY:TWA 400 ppm (1200 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 400 ppm (1200 mg/m3);STEL 500 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 32590 No. of Facilities: 17282 (estimated) No. of Industries: 112 No. of Occupations: 82 No. of Employees: 161572 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 32590 No. of Facilities: 21212 (estimated) No. of Industries: 104 No. of Occupations: 78 No. of Employees: 272746 (estimated) No. of Female Employees: 35683 (estimated)

 Safety Information

[ Symbol ]: GHS02 GHS07
GHS02, GHS07
[ Signal Word ]: Danger
[ Hazard Statements ]: H224-H302-H336
[ Supplemental HS ]: May form explosive peroxides., Repeated exposure may cause skin dryness or cracking.
[ Precautionary Statements ]: P210-P261
[ Personal Protective Equipment ]: Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)
[ Hazard Codes ]: F+:Highlyflammable;Xn:Harmful;
[ Risk Phrases ]: R12;R19;R22;R66;R67
[ Safety Phrases ]: S9-S16-S29-S33-S45-S36/37
[ RIDADR ]: UN 1155 3/PG 1
[ WGK Germany ]: 1
[ RTECS ]: KI5775000
[ Packaging Group ]: I
[ Hazard Class ]: 3
[ HS Code ]: 2909110000

 Customs

[ HS Code ]: 2909110000

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 Synonyms

EINECS 200-467-2
MFCD00144265