Tyramine

Modify Date: 2024-01-02 17:52:41

Tyramine structure	Common Name	Tyramine
	CAS Number	51-67-2	Molecular Weight	137.179
	Density	1.1±0.1 g/cm3	Boiling Point	275.1±23.0 °C at 760 mmHg
	Molecular Formula	C₈H₁₁NO	Melting Point	160-162 °C(lit.)
	MSDS	Chinese USA	Flash Point	141.3±13.3 °C
	Symbol	GHS07	Signal Word	Warning

Use of Tyramine

Tyramine is an indirectly acting sympathomimetic amine that releases norepinephrine from presynaptic nerve terminals.

Name	tyramine
Synonym	More Synonyms

Description	Tyramine is an indirectly acting sympathomimetic amine that releases norepinephrine from presynaptic nerve terminals.
Related Catalog	Research Areas >> Neurological Disease Natural Products >> Others
Target	Human Endogenous Metabolite
In Vitro	Tyramine is an indirectly acting sympathomimetic amine that releases norepinephrine from presynaptic nerve terminals[1]. Tyramine potentiates the postsynaptic inhibitory effects of norepinephrine on the firing of cortical neurones in the rat[2]. Although tyramine exists in three isomerie forms, the orthoisomer and metaisomers are present in very low concentrations and it is the paraisomer that is implied when reference is made to tyramine. The tyramines are generally present in nanogram/gram concentrations in brain tissue, but they have a very rapid turnover. The CNS role of tyramine is unclear, it has been suggested that it is involved in the modulation of dopamine synthesis and may also regulate norepinephrine turnover[3].
References	[1]. Harrison WM, et al. The tyramine challenge test as a marker for melancholia. Arch Gen Psychiatry. 1984 Jul;41(7):681-5. [2]. BURN JH, et al. The action of sympathomimetic amines in animals treated with reserpine. J Physiol. 1958 Dec 4;144(2):314-36. [3]. Juorio AV, et al. A possible role for tyramines in brain function and some mental disorders. Gen Pharmacol. 1982;13(3):181-3.

Density	1.1±0.1 g/cm3
Boiling Point	275.1±23.0 °C at 760 mmHg
Melting Point	160-162 °C(lit.)
Molecular Formula	C₈H₁₁NO
Molecular Weight	137.179
Flash Point	141.3±13.3 °C
Exact Mass	137.084061
PSA	46.25000
LogP	1.38
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.600
Storage condition	Refrigerator, Under Inert Atmosphere
Stability	Stable. Incompatible with strong acids, strong oxidizing agents.
Water Solubility	1g/95mL (15 ºC)

Tyramine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SJ5950000

CHEMICAL NAME :: Phenol, p-(2-aminoethyl)-

CAS REGISTRY NUMBER :: 51-67-2

BEILSTEIN REFERENCE NO. :: 1099914

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C8-H11-N-O

MOLECULAR WEIGHT :: 137.20

WISWESSER LINE NOTATION :: Z2R DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 229 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - sympathomimetic

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracervical

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 137 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 240,19,1990

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	SJ5950000
HS Code	2922299090

Precursor 9
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DownStream 10
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HS Code	2922299090
Summary	2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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Phenol, 4-(ethylamino)-

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Tyramin

MFCD00008193

4-Ethylaminophenol

Tocosine

4-(2-aminoethyl)phenol

4-(2-aminoethyl)-pheno

p-Hydroxyphenylethylamine

Tyrosamine

Systogene

4-Hydroxyphenethylamine

p-Tyramine

4-(Ethylamino)phenol

4-(Ethylamino)benzolol

2-(4-Hydroxyphenyl)ethylamine

EINECS 200-115-8

4-hydroxy-phenethylamine

BioBioPha
China
Product Name: Tyramine
Price: ￥Inquiry/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Tyramine
Price: ￥218.0/20mg ￥348.0/100g ￥158.0/25g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

Zhejiang Hangyu API Co., Ltd
China
Product Name: 2- (4-Hydroxyphenyl) Ethylamine
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Tyramine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: ￥550/10 mM * 1 mL in DMSO

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Tyramine

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