Butein structure
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Common Name | Butein | ||
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CAS Number | 487-52-5 | Molecular Weight | 272.25 | |
Density | 1.5±0.1 g/cm3 | Boiling Point | 560.9±50.0 °C at 760 mmHg | |
Molecular Formula | C15H12O5 | Melting Point | 216°C | |
MSDS | Chinese USA | Flash Point | 307.1±26.6 °C |
Use of ButeinButein, a plant polyphenol isolated from Rhus verniciflua, inhibit the activation of protein tyrosine kinase and EGFR. target: EGFR [1]In vitro: 1) Butein inhibited the activation of AKT, extracellular signal-regulated kinase (ERKs) and p38 kinases in the presence of cisplatin.[2] 2) FoxO3a and its downstream molecules play a role in the synergistic effects of butein and cisplatin.[2]3) Butein suppresses cell proliferation and enhances apoptosis in paclitaxel-resistant ovarian cancer cells.[3]4) Butein activates FOXO3a/p27kip1 pathway in ALL cell lines.[4]5) Butein inhibited not only the epidermal growth factor (EGF)-stimulated auto-phosphotyrosine level of EGF receptor in HepG2 cells but also tyrosine-specific protein kinase activities of EGF receptor (IC50= 65 μM) and p60c-src(IC50= 65 μM)In vivo: 1) Butein in combination with cisplatin suppresses tumor growth and increases FoxO3a expression.[1] |
Name | butein |
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Synonym | More Synonyms |
Description | Butein, a plant polyphenol isolated from Rhus verniciflua, inhibit the activation of protein tyrosine kinase and EGFR. target: EGFR [1]In vitro: 1) Butein inhibited the activation of AKT, extracellular signal-regulated kinase (ERKs) and p38 kinases in the presence of cisplatin.[2] 2) FoxO3a and its downstream molecules play a role in the synergistic effects of butein and cisplatin.[2]3) Butein suppresses cell proliferation and enhances apoptosis in paclitaxel-resistant ovarian cancer cells.[3]4) Butein activates FOXO3a/p27kip1 pathway in ALL cell lines.[4]5) Butein inhibited not only the epidermal growth factor (EGF)-stimulated auto-phosphotyrosine level of EGF receptor in HepG2 cells but also tyrosine-specific protein kinase activities of EGF receptor (IC50= 65 μM) and p60c-src(IC50= 65 μM)In vivo: 1) Butein in combination with cisplatin suppresses tumor growth and increases FoxO3a expression.[1] |
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Related Catalog | |
Target |
EGFR |
References |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 560.9±50.0 °C at 760 mmHg |
Melting Point | 216°C |
Molecular Formula | C15H12O5 |
Molecular Weight | 272.25 |
Flash Point | 307.1±26.6 °C |
PSA | 17.07000 |
LogP | 2.66 |
Appearance of Characters | solid | yellow |
Vapour Pressure | 0.0±1.6 mmHg at 25°C |
Index of Refraction | 1.748 |
Storage condition | -20°C |
Water Solubility | DMSO: >50 mg/mL |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Safety Phrases | S22-S24/25 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
Precursor 9 | |
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DownStream 6 | |
Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a.
Int. J. Mol. Med. 36 , 957-66, (2015) Drug resistance remains a major challenge in cancer therapy. Butein, a polyphenolic compound, has been shown to exhibit anticancer activity through the inhibition of the activation of the protein kina... |
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Butein, a novel dual inhibitor of MET and EGFR, overcomes gefitinib-resistant lung cancer growth.
Mol. Carcinog. 54(4) , 322-31, (2015) Lung cancer is a leading cause of death worldwide and MET amplification is a major therapeutic limitation in acquired-resistance lung cancer. We hypothesized that butein, a phytochemical, can overcome... |
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Butein induces apoptosis in human uveal melanoma cells through mitochondrial apoptosis pathway.
Curr. Eye Res. 37 , 730-739, (2012) To study the cytotoxic effects and related signaling pathways of butein on human uveal melanoma cells in vitro.Three human uveal melanoma cell lines (M17, SP6.5, and C918), retinal pigment epithelial ... |
Chalcone, 2',3,4,4'-tetrahydroxy- (7CI,8CI) |
MFCD00017300 |
(E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one |
(2E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one |
(2E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one |
Einecs 207-659-5 |
2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-, (2E)- |
Butein,2',3,4,4'-Tetrahydroxychalcone |
Butein |
2',3,4,4'-TETRAHYDROCHALCONE |
3,4,2',4'-TETRAHYDROXYCHALCONE |
QR CQ DV1U1R CQ DQ &&E Form |
2',3,4,4'-TETRAHYDROXYCHALCONE |
(E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one |
2′,3,4,4′-Tetrahydroxychalcone |