487-52-5

487-52-5 structure

Name: Butein
Chemical Name: butein
CAS Number: 487-52-5
Molecular Formula: C₁₅H₁₂O₅
Molecular Weight: 272.25
Catalog: Natural product Chalcone
Create Date: 2018-08-26 13:56:14
Modify Date: 2024-01-05 13:18:12
Butein, a plant polyphenol isolated from Rhus verniciflua, inhibit the activation of protein tyrosine kinase and EGFR. target: EGFR [1]In vitro: 1) Butein inhibited the activation of AKT, extracellular signal-regulated kinase (ERKs) and p38 kinases in the presence of cisplatin.[2] 2) FoxO3a and its downstream molecules play a role in the synergistic effects of butein and cisplatin.[2]3) Butein suppresses cell proliferation and enhances apoptosis in paclitaxel-resistant ovarian cancer cells.[3]4) Butein activates FOXO3a/p27kip1 pathway in ALL cell lines.[4]5) Butein inhibited not only the epidermal growth factor (EGF)-stimulated auto-phosphotyrosine level of EGF receptor in HepG2 cells but also tyrosine-specific protein kinase activities of EGF receptor (IC50= 65 μM) and p60c-src(IC50= 65 μM)In vivo: 1) Butein in combination with cisplatin suppresses tumor growth and increases FoxO3a expression.[1]

Name	butein
Synonyms	Chalcone, 2',3,4,4'-tetrahydroxy- (7CI,8CI) MFCD00017300 (E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one (2E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one (2E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one Einecs 207-659-5 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-, (2E)- Butein,2',3,4,4'-Tetrahydroxychalcone Butein 2',3,4,4'-TETRAHYDROCHALCONE 3,4,2',4'-TETRAHYDROXYCHALCONE QR CQ DV1U1R CQ DQ &&E Form 2',3,4,4'-TETRAHYDROXYCHALCONE (E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one 2′,3,4,4′-Tetrahydroxychalcone

Description	Butein, a plant polyphenol isolated from Rhus verniciflua, inhibit the activation of protein tyrosine kinase and EGFR. target: EGFR [1]In vitro: 1) Butein inhibited the activation of AKT, extracellular signal-regulated kinase (ERKs) and p38 kinases in the presence of cisplatin.[2] 2) FoxO3a and its downstream molecules play a role in the synergistic effects of butein and cisplatin.[2]3) Butein suppresses cell proliferation and enhances apoptosis in paclitaxel-resistant ovarian cancer cells.[3]4) Butein activates FOXO3a/p27kip1 pathway in ALL cell lines.[4]5) Butein inhibited not only the epidermal growth factor (EGF)-stimulated auto-phosphotyrosine level of EGF receptor in HepG2 cells but also tyrosine-specific protein kinase activities of EGF receptor (IC50= 65 μM) and p60c-src(IC50= 65 μM)In vivo: 1) Butein in combination with cisplatin suppresses tumor growth and increases FoxO3a expression.[1]
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Natural Products >> Phenols Research Areas >> Cancer
Target	EGFR
References	[1]. Er-Bin Yang et al. Butein, a Specific Protein Tyrosine Kinase Inhibitor. Biochem Biophys Res Commun, 1998 Apr 17, 245(2):435-8. [2]. Zhang L et al. Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Int J Mol Med, 2015 Oct, 36(4):957-66 [3]. Hyeong Sim Choi et al. Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation. BMC Complement Altern Med, 2016, 16: 122. [4]. Tang YL et al. Butein inhibits cell proliferation and induces cell cycle arrest in acute lymphoblastic leukemia via FOXO3a/p27kip1 pathway. Oncotarget, 2016 Apr 5, 7(14):18651-64.

Density	1.5±0.1 g/cm3
Boiling Point	560.9±50.0 °C at 760 mmHg
Melting Point	216°C
Molecular Formula	C₁₅H₁₂O₅
Molecular Weight	272.25
Flash Point	307.1±26.6 °C
PSA	17.07000
LogP	2.66
Appearance	solid \| yellow
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.748
Storage condition	-20°C
Water Solubility	DMSO: >50 mg/mL

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3

Precursor 9
120078-41-3 89-84-9 139-85-5 61854-89-5
136258-01-0 6515-05-5 6515-06-6 100-52-7
67756-04-1
DownStream 6
485-63-2 503-17-3 89-84-9 99-50-3
108-46-3 100634-10-4

487-52-5	21849-70-7
499-29-6	30382-19-5