Butein
Butein structure
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Common Name | Butein | ||
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| CAS Number | 487-52-5 | Molecular Weight | 272.25 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 560.9±50.0 °C at 760 mmHg | |
| Molecular Formula | C15H12O5 | Melting Point | 216°C | |
| MSDS | Chinese USA | Flash Point | 307.1±26.6 °C | |
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Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a.
Int. J. Mol. Med. 36 , 957-66, (2015) Drug resistance remains a major challenge in cancer therapy. Butein, a polyphenolic compound, has been shown to exhibit anticancer activity through the inhibition of the activation of the protein kinase B (PKB/AKT) and mitogen-activated protein kinase (MAPK) ... |
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Butein, a novel dual inhibitor of MET and EGFR, overcomes gefitinib-resistant lung cancer growth.
Mol. Carcinog. 54(4) , 322-31, (2015) Lung cancer is a leading cause of death worldwide and MET amplification is a major therapeutic limitation in acquired-resistance lung cancer. We hypothesized that butein, a phytochemical, can overcome gefitinib-induced resistance by targeting both EGFR and ME... |
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Butein induces apoptosis in human uveal melanoma cells through mitochondrial apoptosis pathway.
Curr. Eye Res. 37 , 730-739, (2012) To study the cytotoxic effects and related signaling pathways of butein on human uveal melanoma cells in vitro.Three human uveal melanoma cell lines (M17, SP6.5, and C918), retinal pigment epithelial (RPE) cells and scleral fibroblasts were treated with butei... |
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Effects of natural nuclear factor-kappa B inhibitors on anticancer drug efflux transporter human P-glycoprotein.
Biomed. Pharmacother. 70 , 140-5, (2015) Drug efflux transporter P-glycoprotein plays an important role in cancer chemotherapy. The nuclear factor-κB (NF-κB) transcription factors play critical roles in development and progression of cancer. In this study, the effects of natural compounds that can i... |
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Effects of phytochemicals on in vitro anti-inflammatory activity of Bifidobacterium adolescentis.
Biosci. Biotechnol. Biochem. 79 , 799-807, (2015) Probiotics have been shown to improve the condition of not only the human gastrointestinal tract but also the entire body. We found that quercetin enhances the anti-inflammatory activity of Bifidobacterium adolescentis, which is abundant in human intestines. ... |
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The depletion of securin enhances butein-induced apoptosis and tumor inhibition in human colorectal cancer.
Chem. Biol. Interact. 220 , 41-50, (2014) Butein (3,4,2',4'-tetrahydroxychalcone) is a promising natural polyphenolic compound that shows the growth inhibitory activity in human cancer cells; however, the precise mechanism is still unclear. Securin plays pivotal role in cancer cell proliferation and ... |
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Butein suppresses breast cancer growth by reducing a production of intracellular reactive oxygen species.
J. Exp. Clin. Cancer Res 33 , 51, (2014) Butein has various functions in human diseases including cancer. While anti-cancer effects of butein have been revealed, it is urgent to understand a unique role of butein against cancer. In this study, we demonstrate that butein inhibition of reactive oxygen... |
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Butein Shows Cytotoxic Effects and Induces Apoptosis in Human Ovarian Cancer Cells.
Am. J. Chin. Med. 43 , 769-82, (2015) Butein is a polyphenol, one of the compounds of chalcones, which are flavonoids that are widely biosynthesized in plants, and exhibits different pharmacological activities. Plants containing butein have been used in Chinese traditional medicine. Recently, it ... |
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Electrochemical oxidation of butein at glassy carbon electrodes.
Bioelectrochemistry 91 , 62-9, (2013) The electrochemical oxidation of flavonoid butein is studied at glassy carbon electrodes in phosphate and citrate buffer solutions of different pH values, and 1M perchloric acid aqueous solutions by cyclic and square wave voltammetries. The oxidation peak cor... |
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High-level semi-synthetic production of the potent antimalarial artemisinin.
J. Mol. Model. 21 , 247, (2015) In 2010 there were more than 200 million cases of malaria, and at least 655,000 deaths. The World Health Organization has recommended artemisinin-based combination therapies (ACTs) for the treatment of uncomplicated malaria caused by the parasite Plasmodium f... |