farnesol

Modify Date: 2024-01-03 17:27:28

farnesol Structure
farnesol structure
Common Name farnesol
CAS Number 4602-84-0 Molecular Weight 222.366
Density 0.9±0.1 g/cm3 Boiling Point 283.4±0.0 °C at 760 mmHg
Molecular Formula C15H26O Melting Point N/A
MSDS Chinese USA Flash Point 96.1±0.0 °C
Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning

 Use of farnesol


Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans, and has the activity in inhibiting bacteria.

 Names

Name farnesol
Synonym More Synonyms

 farnesol Biological Activity

Description Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans, and has the activity in inhibiting bacteria.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans. It is also shown that this molecule presents inhibitory effects against non-albicans Candida species, Paracoccidioides brasiliensis and bacteria. The minimum inhibitory concentrations (MICs) are determined in accordance with the M27-A3 protocol as described and Farnesol is tested at a concentration range of 0.29-150 μM. It is observed that Farnesol presents an inhibitory activity against C. neoformans and C. gattii (MIC range: 0.29-75.0 μM). Although Farnesol does not significantly alter phospholipase activity, a tendency to decrease this activity is observed[1].
References

[1]. Cordeiro Rde A, et al. Farnesol inhibits in vitro growth of the Cryptococcus neoformans species complex with no significant changes in virulence-related exoenzymes. Vet Microbiol. 2012 Oct 12;159(3-4):375-80.

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 283.4±0.0 °C at 760 mmHg
Molecular Formula C15H26O
Molecular Weight 222.366
Flash Point 96.1±0.0 °C
Exact Mass 222.198364
PSA 20.23000
LogP 5.31
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.485
Storage condition −20°C
Stability Stable. Combustible. Incompatible with strong oxidizing agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
JR4979000
CHEMICAL NAME :
2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl-
CAS REGISTRY NUMBER :
4602-84-0
LAST UPDATED :
199712
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C15-H26-O
MOLECULAR WEIGHT :
222.41
WISWESSER LINE NOTATION :
Q2UY1&3UY1&3UY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
443 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Insect - not otherwise specified Ovary
DOSE/DURATION :
100 umol/L
REFERENCE :
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 43,1285,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5190 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)

 Safety Information

Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H315-H317-H319-H411
Precautionary Statements P273-P280-P333 + P313-P337 + P313-P391-P501
Personal Protective Equipment Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
Hazard Codes Xi: Irritant;
Risk Phrases R24/25
Safety Phrases S22-S24/25
RIDADR UN 3082 9 / PGIII
WGK Germany 3
RTECS JR4979000
HS Code 2905290000

 Customs

HS Code 2905290000
Summary 2905290000 unsaturated monohydric alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Articles81

More Articles
Developmentally regulated sesquiterpene production confers resistance to Colletotrichum gloeosporioides in ripe pepper fruits.

PLoS ONE 9(10) , e109453, (2014)

Sesquiterpenoid capsidiol, exhibiting antifungal activity against pathogenic fungus, is accumulated in infected ripe pepper fruits. In this study, we found a negative relation between the capsidiol le...

Farnesol induces apoptosis-like cell death in the pathogenic fungus Aspergillus flavus.

Mycologia 106(5) , 881-8, (2014)

Farnesol (FOH) is known to induce apoptosis in some fungi and mammalian cells. We treated Aspergillus flavus, one of the leading causes of human invasive aspergillosis and a key producer of the most p...

Pluronics-Formulated Farnesol Promotes Efficient Killing and Demonstrates Novel Interactions with Streptococcus mutans Biofilms.

PLoS ONE 10 , e0133886, (2015)

Streptococcus mutans is the primary causative agent of dental caries, one of the most prevalent diseases in the United States. Previously published studies have shown that Pluronic-based tooth-binding...

 Synonyms

(2-trans,6-trans)-farnesol
(E,E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol
Stirrup-TPW
Stirrup-HB
(2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trien-1-ol
trans,trans-3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol
(2E,6E)-Farnesol
all-trans-farnesol
all-E-Farnesol
Farnesoi
EINECS 225-004-1
MFCD00002918
farnesyl bromide
2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl-, (E,E)-
(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol
trans,trans-Farnesol
2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl-, (2E,6E)-
3,7,10-trimethyl-2,6,10-dodecatrien-1-ol
ALL TRANS FARNESOL
FARNESOLP
trans-Farnesol
Farnesol,(E,E)
3,7,11-Trimethyl-2,6,10-dodecatrienol
(E)-farnesol
farnesyl alcohol
(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol
3,7,11-Trimethyl-2,6,10-Dodecatrien-1-ol
E,E-farnesol
Stirrup-CRW
Polyprenol
Stirrup-H
Farnesol
(E,E)-Farnesol
3,7,11-Trimethyldodeca-2,6,10-trien-1-ol
3,7,11-Trimethyldodeca-2-trans,6-trans,10-trien-1-ol
fci119a
Inhibitor A2
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