isoprene

MOLECULAR FORMULA :

C5-H8

MOLECULAR WEIGHT :

68.13

WISWESSER LINE NOTATION :

1UY1&1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

180 gm/m3/4H

TOXIC EFFECTS :

Behavioral - general anesthetic Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

139 gm/m3/2H

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

157 mg/kg/9W-C

TOXIC EFFECTS :

Behavioral - alteration of classical conditioning

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

3400 mg/m3/22W-I

TOXIC EFFECTS :

Brain and Coverings - changes in brain weight Lungs, Thorax, or Respiration - changes in lung weight Kidney, Ureter, Bladder - changes in kidney weight

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

3400 mg/m3/17W-I

TOXIC EFFECTS :

Behavioral - changes in psychophysiological tests

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

3400 mg/m3/17W-I

TOXIC EFFECTS :

Behavioral - alteration of classical conditioning Blood - changes in leukocyte (WBC) count

TYPE OF TEST :

Micronucleus test

MUTATION DATA

TEST SYSTEM :

Rodent - mouse

DOSE/DURATION :

438 ppm/6H/12D (Continuous)

REFERENCE :

MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,141,1988 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,215,1994 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,215,1994 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,215,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-POLAND:TWA 100 mg/m3 JAN 1993 OEL-RUSSIA:STEL 40 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 40940 No. of Facilities: 2278 (estimated) No. of Industries: 36 No. of Occupations: 43 No. of Employees: 58102 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 40940 No. of Facilities: 123 (estimated) No. of Industries: 6 No. of Occupations: 15 No. of Employees: 3703 (estimated) No. of Female Employees: 578 (estimated)