alpha-Bisabolol

Modify Date: 2024-01-02 20:33:16

alpha-Bisabolol Structure
alpha-Bisabolol structure
Common Name alpha-Bisabolol
CAS Number 515-69-5 Molecular Weight 222.366
Density 0.9±0.1 g/cm3 Boiling Point 314.5±11.0 °C at 760 mmHg
Molecular Formula C15H26O Melting Point N/A
MSDS N/A Flash Point 113.2±15.6 °C

 Use of alpha-Bisabolol


alpha-Bisabolol is a nontoxic sesquiterpene alcohol present in natural essential oil, with anticancer activity. alpha-Bisabolol exerts selective anticancer effect on A549 NSCLC cells (IC50=15 μM) via induction of cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol also strongly induces apoptosis in glioma cells[1][2].

 Names

Name alpha-Bisabolol
Synonym More Synonyms

 alpha-Bisabolol Biological Activity

Description alpha-Bisabolol is a nontoxic sesquiterpene alcohol present in natural essential oil, with anticancer activity. alpha-Bisabolol exerts selective anticancer effect on A549 NSCLC cells (IC50=15 μM) via induction of cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol also strongly induces apoptosis in glioma cells[1][2].
Related Catalog
References

[1]. Wu S, et al. Anticancer effects of α-Bisabolol in human non-small cell lung carcinoma cells are mediated via apoptosis induction, cell cycle arrest, inhibition of cell migration and invasion and upregulation of P13K/AKT signalling pathway. J BUON. 2018 Sep-Oct;23(5):1407-1412.

[2]. Cavalieri E, et al. alpha-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells. Biochem Biophys Res Commun. 2004 Mar 12;315(3):589-94.

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 314.5±11.0 °C at 760 mmHg
Molecular Formula C15H26O
Molecular Weight 222.366
Flash Point 113.2±15.6 °C
Exact Mass 222.198364
PSA 20.23000
LogP 5.07
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.494
Stability Stable. Combustible. Incompatible with strong oxidizing agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MJ9685000
CHEMICAL NAME :
5-Hepten-2-ol, 6-methyl-2-(4-methyl-3-cyclohexen-1-yl)-
CAS REGISTRY NUMBER :
515-69-5
LAST UPDATED :
199709
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C15-H26-O
MOLECULAR WEIGHT :
222.41
WISWESSER LINE NOTATION :
L6UTJ A1 DXQ1&3UY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14850 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,615,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
11350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,615,1969 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1661 No. of Facilities: 357 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 3923 (estimated) No. of Female Employees: 2853 (estimated)

 Safety Information

Risk Phrases R33
RIDADR 3439.0
WGK Germany 2
RTECS MJ9685000
Hazard Class 6.1
HS Code 29061900

 Synthetic Route

 Customs

HS Code 29061900

 Synonyms

MFCD03846910
rel-(2R)-6-Methyl-2-[(1R)-4-methylcyclohex-3-en-1-yl]hept-5-en-2-ol
3-Cyclohexene-1-methanol, α,4-dimethyl-α-(4-methyl-3-penten-1-yl)-, (αR,1R)-
)-α-Bisabolol
a-Bisabolol
α-Bisabolol
3-Cyclohexene-1-methanol, α,4-dimethyl-α-(4-methyl-3-pentenyl)-, (αR,1R)-rel-
dl-a-Bisabolol
(+/-)-α-Bisabolol
(2R)-6-Methyl-2-[(1R)-4-methylcyclohex-3-en-1-yl]hept-5-en-2-ol
6-Methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol
EINECS 208-205-9
(2R)-6-Methyl-2-[(1R)-4-methyl-3-cyclohexen-1-yl]-5-hepten-2-ol
Dragosantol
(R*,R*)-6-Dethyl-2-(4-methyl-3-cyclohexen-1-yl)-5-Hepten-2-ol
(±)-a-Bisabolol