|CAS Number||372-75-8||Molecular Weight||175.186|
|Density||1.3±0.1 g/cm3||Boiling Point||386.7±42.0 °C at 760 mmHg|
|Molecular Formula||C6H13N3O3||Melting Point||214 °C|
|MSDS||Chinese USA||Flash Point||187.7±27.9 °C|
Use of L(+)-Citrulline
L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.
|Description||L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.|
Human Endogenous Metabolite
|In Vitro||L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway. L-Citrulline is also obtained during the degradation of asymmetric dimethylarginine (ADMA), the process catalyzed by dimethylarginine dimethylaminohydrolase (DDAH), yielding dimethylamine (DMA) as a coproduct.|
10 mM in DMSO
|Shipping||Room temperature in continental US; may vary elsewhere|
. Fleszar MG, et al. Quantitative Analysis of l-Arginine, Dimethylated Arginine Derivatives, l-Citrulline, and Dimethylamine in Human Serum Using Liquid Chromatography-Mass Spectrometric Method. Chromatographia. 2018;81(6):911-921.
|Related Molecules||3-Methyladenine | Hydrocortisone | Acetylcysteine | Tretinoin | Melatonine | Prostaglandin E2 | Nicotinamide | Adenosine triphosphate | 4-Acetamidophenol | Prostaglandin E1 | Dehydroepiandrosterone | Corticosterone | Progesterone | Docosahexaenoic Acid | NAD+|
*The above documents are provided by Medchemexpress and are for scientific research only.
|Boiling Point||386.7±42.0 °C at 760 mmHg|
|Melting Point||214 °C|
|Flash Point||187.7±27.9 °C|
|Vapour Pressure||0.0±1.9 mmHg at 25°C|
|Index of Refraction||1.531|
|Water Solubility||200 g/L (20 ºC)|
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: None Listed.
Section 3 - HAZARDS IDENTIFICATION
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
May cause eye irritation.
May cause skin irritation.
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
No information found.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid.
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section.
Section 7 - HANDLING and STORAGE
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Store in a cool, dry place. Keep container closed when not in use.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 372-75-8: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Wear appropriate protective gloves to prevent skin exposure.
Wear appropriate protective clothing to prevent skin exposure.
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Solid
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 220 deg C (decomposes)
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: Soluble in water.
Specific Gravity/Density: Not available.
Molecular Formula: C6H13N3O3
Molecular Weight: 175.1093
Section 10 - STABILITY AND REACTIVITY
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatibilities with Other Materials:
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
CAS# 372-75-8 unlisted.
L-Citrulline - Not listed by ACGIH, IARC, or NTP.
Section 12 - ECOLOGICAL INFORMATION
Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.
Section 14 - TRANSPORT INFORMATION
No information available.
No information available.
No information available.
Section 15 - REGULATORY INFORMATION
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 372-75-8: 0
CAS# 372-75-8 is listed on Canada's NDSL List.
CAS# 372-75-8 is not listed on Canada's Ingredient Disclosure List.
CAS# 372-75-8 is listed on the TSCA inventory.
SECTION 16 - ADDITIONAL INFORMATION
|Summary||2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%|
Development of High-purity Certified Reference Materials for 17 Proteinogenic Amino Acids by Traceable Titration Methods.
Anal. Sci. 31 , 805-14, (2015)
To ensure the reliability of amino acid analyses, the National Metrology Institute of Japan of the National Institute of Advanced Industrial Science and Technology (NMIJ/AIST) has developed high-purit...
Down regulation of NO signaling in Trypanosoma cruzi upon parasite-extracellular matrix interaction: changes in protein modification by nitrosylation and nitration.
PLoS Negl. Trop. Dis. 9 , e0003683, (2015)
Adhesion of the Trypanosoma cruzi trypomastigotes, the causative agent of Chagas' disease in humans, to components of the extracellular matrix (ECM) is an important step in host cell invasion. The sig...
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.
Nature 457(7231) , 910-4, (2009)
Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the i...
|(S)-2-Amino-5-ureidopentanoic acid L-2-Amino-5-ureidovaleric acid|
|L-Ornithine, N5- (aminocarbonyl)-|
|(S)-2-amino-5-(carbamoyl amino)pentanoic acid|