L-Arginine hydrochloride

Modify Date: 2024-01-02 17:24:36

L-Arginine hydrochloride structure	Common Name	L-Arginine hydrochloride
	CAS Number	1119-34-2	Molecular Weight	210.662
	Density	1.42	Boiling Point	409.1ºC at 760 mmHg
	Molecular Formula	C₆H₁₅ClN₄O₂	Melting Point	226-230 °C(lit.)
	MSDS	Chinese USA	Flash Point	201.2ºC

Use of L-Arginine hydrochloride

L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.Target: OthersArginine is an α-amino acid. It was first isolated in 1886. The L-form is one of the 20 most common natural amino acids. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that code for arginine during protein synthesis. In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice.

Name	2-Amino-5-guanidinovaleric acid monohydrochloride
Synonym	More Synonyms

Description	L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.Target: OthersArginine is an α-amino acid. It was first isolated in 1886. The L-form is one of the 20 most common natural amino acids. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that code for arginine during protein synthesis. In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Others Natural Products >> Others
References	[1]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45. [2]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12. [3]. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17.

Description

Related Catalog

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Others

Natural Products >> Others

References

[1]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45.

[2]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12.

[3]. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17.

Density	1.42
Boiling Point	409.1ºC at 760 mmHg
Melting Point	226-230 °C(lit.)
Molecular Formula	C₆H₁₅ClN₄O₂
Molecular Weight	210.662
Flash Point	201.2ºC
Exact Mass	210.088348
PSA	125.22000
LogP	1.35480

L-Arginine hydrochloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CF1995500

CHEMICAL NAME :: Arginine, monohydrochloride, L-

CAS REGISTRY NUMBER :: 1119-34-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C6-H14-N4-O2.Cl-H

MOLECULAR WEIGHT :: 210.70

WISWESSER LINE NOTATION :: MUYZM3YZVQ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12 gm/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 62,49,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3793 mg/kg

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 58,253,1955 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 90 mg/kg

SEX/DURATION :: female 1-6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year: 51,553,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81859 No. of Facilities: 86 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 857 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81859 No. of Facilities: 585 (estimated) No. of Industries: 3 No. of Occupations: 13 No. of Employees: 5477 (estimated) No. of Female Employees: 2954 (estimated)

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S37/39-S26-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	CF1995500
HS Code	2922499990

Precursor 6
CAS#:1207348-80-8 micropeptin MZ771 CAS#:1207348-70-6 micropeptin MZ859 CAS#:1207348-72-8 micropeptin MZ939A CAS#:1207348-74-0 micropeptin MZ925
CAS#:1207348-76-2 micropeptin MZ939B CAS#:1207348-78-4 micropeptin MZ1019
DownStream 10
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CAS#:15706-88-4 H-Arg-Asp-OH CAS#:35455-33-5 Bufa-20,22-dien... CAS#:113-00-8 guanidine CAS#:70-26-8 L-Ornithine
CAS#:13726-76-6 Boc-Arg-OH CAS#:155-84-0 Ac-Arg-OH

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

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levargin

L-Arginine HCl

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L-Arginine hydrochloride

L-ARG HCL

(S)-2-Amino-5-guanidinopentanoic acid hydrochloride

(S)-(+)-Arginine hydrochloride,L-Arginine hydrochloride

L-Arginine hydrochloride (1:1)

(S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride

2-Amino-5-guanidinovalericacidmonohydrochloride

anhydrous L-arginine monohydrochloride

L-Arginine HCl (L-Arg)

Arginine hydrochloride

L-Arginine.HCl

Arginine Muriate

S-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride

(S)-arginine hydrochloride

L(+)-Arginine hydrochloride

ARG,HCL

(2S)-2-Amino-5-carbamimidamidopentansäurehydrochlorid

L-Arginine, hydrochloride (1:1)

EINECS 214-275-1

L-Arginine Monohydrochloride (VAN)

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detoxargin

r-gene

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argivene

MFCD00064550

H-Arg-OH.HCl

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acide (2S)-2-amino-5-carbamimidamidopentanoïque chlorhydrate

L-Arginine monohydrochloride

minophagena

L-Arginine (hydrochloride)

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: L-Arginine hydrochloride
Price: ￥98.0/200mg ￥108.0/100g ￥318.0/500g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: L-Arginine HCl
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Nanjing Peptide Biotech Ltd
China
Product Name: L-Arginine hydrochloride
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Stocking Period: 7 Day
Contact: jom

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: L-ARGININE HCL
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: L(+)-Arginine hydrochloride
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: L-Arginine hydrochloride
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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