Hedgehog-IN-7d
Modify Date: 2025-12-01 10:41:12
Hedgehog-IN-7d structure
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Common Name | Hedgehog-IN-7d | ||
|---|---|---|---|---|
| CAS Number | 330796-24-2 | Molecular Weight | 490.837 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C23H15ClF4N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Hedgehog-IN-7dHedgehog-IN-7d is a potent, cell-permeable Hedgehog (Hh) pathway inhibitor that inhibits Gli transcription activity with an IC50 value of 70 nM.. |
| Name | 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[3-(4-fluorophenyl)-4-oxoquinazolin-2-yl]methyl]urea |
|---|---|
| Synonym | More Synonyms |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C23H15ClF4N4O2 |
| Molecular Weight | 490.837 |
| Exact Mass | 490.081970 |
| PSA | 79.51000 |
| LogP | 5.57 |
| Index of Refraction | 1.623 |
| InChIKey | NYOXUHUPXGFHIB-UHFFFAOYSA-N |
| SMILES | O=C(NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1 |
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~96%
Hedgehog-IN-7d CAS#:330796-24-2 |
| Literature: Curtis, Inc. Patent: US6545005 B1, 2003 ; |
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~99%
Hedgehog-IN-7d CAS#:330796-24-2 |
| Literature: Brunton, Shirley A.; Stibbard, John H. A.; Rubin, Lee L.; Kruse, Lawrence I.; Guicherit, Oivin M.; Boyd, Edward A.; Price, Steven Journal of Medicinal Chemistry, 2008 , vol. 51, # 5 p. 1108 - 1110 |
| Precursor 3 | |
|---|---|
| DownStream 0 | |
| 1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-{[3-(4-fluorophenyl)-4-oxo-3,4-dihydro-2-quinazolinyl]methyl}urea |
| Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]- |