4-Chloro-3-(trifluoromethyl)phenylisocyanate

Modify Date: 2024-01-02 14:28:43

4-Chloro-3-(trifluoromethyl)phenylisocyanate Structure
4-Chloro-3-(trifluoromethyl)phenylisocyanate structure
Common Name 4-Chloro-3-(trifluoromethyl)phenylisocyanate
CAS Number 327-78-6 Molecular Weight 221.564
Density 1.4±0.1 g/cm3 Boiling Point 201.7±0.0 °C at 760 mmHg
Molecular Formula C8H3ClF3NO Melting Point 40-42 °C(lit.)
MSDS Chinese USA Flash Point 99.4±0.0 °C
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 201.7±0.0 °C at 760 mmHg
Melting Point 40-42 °C(lit.)
Molecular Formula C8H3ClF3NO
Molecular Weight 221.564
Flash Point 99.4±0.0 °C
Exact Mass 220.985519
PSA 29.43000
LogP 4.93
Vapour Pressure 0.3±0.3 mmHg at 25°C
Index of Refraction 1.487

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H315-H319-H332-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R20/21/22;R36/37/38
Safety Phrases S7-S26-S27-S37/39-S36/37/39-S45-S23
RIDADR UN 2206 6.1/PG 3
WGK Germany 3
Packaging Group III
Hazard Class 6.1
HS Code 2929109000

 Synthetic Route

~97%

4-Chloro-3-(trifluoromethyl)phenylisocyanate Structure

4-Chloro-3-(tri...

CAS#:327-78-6

Literature: Bioorganic and Medicinal Chemistry, , vol. 21, # 11 p. 2960 - 2967

~%

4-Chloro-3-(trifluoromethyl)phenylisocyanate Structure

4-Chloro-3-(tri...

CAS#:327-78-6

Literature: Justus Liebigs Annalen der Chemie, , vol. 562, p. 75,1114

~%

4-Chloro-3-(trifluoromethyl)phenylisocyanate Structure

4-Chloro-3-(tri...

CAS#:327-78-6

Literature: US2012/53192 A1, ; Page/Page column 4 ;

 Customs

HS Code 2929109000
Summary 2929109000. other isocyanates. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

Sorafenib intermediate 3
Isocyanic Acid 4-Chloro-3-(trifluoromethyl)phenyl Ester
1-chloro-4-isocyanato-2-trifluoromethylbenzene
3-TRIFLUOROMETHYL-4-CHLORO-PHENYL ISOCYANATE
4-Cl-3CF3-phenyl isocyanate
4-Chloro-3-(trifluoromethyl)phenyl isocyanate
MFCD00013874
1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene
4-Chloro-3-(trifluoromethyl)phenylisocyanate
Benzene, 1-chloro-4-isocyanato-2-(trifluoromethyl)-
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