Donafenib (Sorafenib D3)

Modify Date: 2024-01-12 18:56:31

Donafenib (Sorafenib D3) structure	Common Name	Donafenib (Sorafenib D3)
	CAS Number	1130115-44-4	Molecular Weight	467.84300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₃ClD₃F₃N₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Donafenib (Sorafenib D3)

Sorafenib D3 (Bay 43-9006 D3) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.

Name	4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-(trideuteriomethyl)pyridine-2-carboxamide
Synonym	More Synonyms

Description	Sorafenib D3 (Bay 43-9006 D3) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Wilhelm SM, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64(19):7099-109.

Molecular Formula	C₂₁H₁₃ClD₃F₃N₄O₃
Molecular Weight	467.84300
Exact Mass	467.10500
PSA	92.35000
LogP	6.08660

Hazard Codes	Xi

Precursor 10
CAS#:573673-43-5 METHYL 4-(4-(3-... CAS#:7436-22-8 Methyl-d3-amine... CAS#:1189975-18-5 [4-(4-Aminophen... CAS#:320-51-4 5-Amino-2-chlor...
CAS#:530-62-1 N,N-Carbonyldii... CAS#:327-78-6 4-Chloro-3-(tri... CAS#:1012058-78-4 4-(4-(3-(4-chlo... CAS#:1129683-83-5 1-(4-chloro-3-(...
CAS#:1189858-48-7 4-chloro-N-(met... CAS#:1187086-96-9 N-[4-chloro-3-(...
DownStream 0

4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-phenyoxy)-N-(methyl-d3)picolinamide

Sorafenib-d3

4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-(methyl-d3)-2-pyridinecarboxamide

BAY-43-9006-d3

Sorafenib D3

SIMVASTATIN 4'-METHYL ETHER

Sorafenib-methyl-d3

4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-phenoxy)-N-(methyl-d3)picolinamide

N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-(methyl-d3)aminoformyl)-4-pyridyloxy)phenyl)urea

DC Chemicals Limited
China
Product Name: Donafenib (Sorafenib D3)
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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