1130115-44-4

1130115-44-4 structure

Name: Donafenib (Sorafenib D3)
Chemical Name: 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-(trideuteriomethyl)pyridine-2-carboxamide
CAS Number: 1130115-44-4
Molecular Formula: C₂₁H₁₃ClD₃F₃N₄O₃
Molecular Weight: 467.84300
Catalog: Research Areas Others
Create Date: 2016-06-23 08:19:11
Modify Date: 2024-01-12 18:56:31
Sorafenib D3 (Bay 43-9006 D3) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.

Name	4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-(trideuteriomethyl)pyridine-2-carboxamide
Synonyms	4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-phenyoxy)-N-(methyl-d3)picolinamide Sorafenib-d3 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-(methyl-d3)-2-pyridinecarboxamide BAY-43-9006-d3 Sorafenib D3 SIMVASTATIN 4'-METHYL ETHER Sorafenib-methyl-d3 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-phenoxy)-N-(methyl-d3)picolinamide N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-(methyl-d3)aminoformyl)-4-pyridyloxy)phenyl)urea

Description	Sorafenib D3 (Bay 43-9006 D3) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Wilhelm SM, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64(19):7099-109.

Hazard Codes	Xi