Donafenib (Sorafenib D3)

Names

[ Name ]:
Donafenib (Sorafenib D3)

[Synonym ]:
4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-phenyoxy)-N-(methyl-d3)picolinamide
Sorafenib-d3
4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-(methyl-d3)-2-pyridinecarboxamide
BAY-43-9006-d3
Sorafenib D3
SIMVASTATIN 4'-METHYL ETHER
Sorafenib-methyl-d3
4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-phenoxy)-N-(methyl-d3)picolinamide
N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-(methyl-d3)aminoformyl)-4-pyridyloxy)phenyl)urea

Biological Activity

[Description]:

Sorafenib D3 (Bay 43-9006 D3) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Wilhelm SM, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64(19):7099-109.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₃ClD₃F₃N₄O₃

[ Molecular Weight ]:
467.84300

[ Exact Mass ]:
467.10500

[ PSA ]:
92.35000

[ LogP ]:
6.08660

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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