GAK inhibitor 49
Modify Date: 2025-10-06 11:47:58
GAK inhibitor 49 structure
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Common Name | GAK inhibitor 49 | ||
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| CAS Number | 319492-82-5 | Molecular Weight | 370.405 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H22N2O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GAK inhibitor 49GAK inhibitor 49 is a potent, selective, ATP-competitive inhibitor of cyclin G-associated kinase (GAK, cell IC50=56 nM) with favourable NAK family selectivity (AAK1, STK16, BMP2K); shows binding to only GAK and RIPK2 in an unbiased MIB/MS experiment in cell lysate. |
| Name | GAK inhibitor 49 |
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| Description | GAK inhibitor 49 is a potent, selective, ATP-competitive inhibitor of cyclin G-associated kinase (GAK, cell IC50=56 nM) with favourable NAK family selectivity (AAK1, STK16, BMP2K); shows binding to only GAK and RIPK2 in an unbiased MIB/MS experiment in cell lysate. |
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| References | References 1. Asquith CRM, et al. ChemMedChem. 2018 Jan 8;13(1):48-66. 2. Pu SY, et al. J Med Chem. 2018 Jul 16. doi: 10.1021/acs.jmedchem.8b00613. View Related Products by Target Other Targets |
| Molecular Formula | C20H22N2O5 |
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| Molecular Weight | 370.405 |
| InChIKey | VYPGLYMWNDRFGZ-UHFFFAOYSA-N |
| SMILES | COc1cc2nccc(Nc3cc(OC)c(OC)c(OC)c3)c2cc1OC |
| Hazard Codes | Xi |
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