393569-31-8
393569-31-8 structure
- Name: sPLA2 inhibitor 1
- Chemical Name: KH064
- CAS Number: 393569-31-8
- Molecular Formula: C31H37NO4
- Molecular Weight: 487.63
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
- Create Date: 2021-01-09 18:01:18
- Modify Date: 2024-01-13 14:10:32
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sPLA2 inhibitor 1, a D-tyrosine derivative, is an orally active, potent secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 29 nM for human nonpancreatic secretory PLA2 isoform IIa (hnpsPLA2-IIa). sPLA2 inhibitor 1 has anti-inflammatory activity[1].
| Name | KH064 |
|---|---|
| Synonyms |
KH064
Benzenepentanoic acid, γ-[(1-oxo-7-phenylheptyl)amino]-4-(phenylmethoxy)-, (γS)- MFCD06411576 sPLA2 inhibitor (4S)-5-[4-(Benzyloxy)phenyl]-4-[(7-phenylheptanoyl)amino]pentanoic acid 5-(4-Benzyloxyphenyl)-4S-(7-phenylheptanoylamino)pentanoic acid |
| Description | sPLA2 inhibitor 1, a D-tyrosine derivative, is an orally active, potent secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 29 nM for human nonpancreatic secretory PLA2 isoform IIa (hnpsPLA2-IIa). sPLA2 inhibitor 1 has anti-inflammatory activity[1]. |
|---|---|
| Related Catalog | |
| Target |
sPLA2:29 nM (IC50) |
| In Vivo | sPLA2 inhibitor 1 (compound 2b; oral; 5 mg/kg/day; on Days 10-13 after inoculation with arthritogen) shows substantial inhibition of the oedema. Drug-treated rats shows mild capsular oedema and minimal infiltration of macrophages into the red pulp[1]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 720.9±60.0 °C at 760 mmHg |
| Molecular Formula | C31H37NO4 |
| Molecular Weight | 487.63 |
| Flash Point | 389.8±32.9 °C |
| Exact Mass | 487.272247 |
| LogP | 6.16 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.573 |
| Storage condition | 2-8°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |