GAK inhibitor 49
Names
[ CAS No. ]:
319492-82-5
[ Name ]:
GAK inhibitor 49
Biological Activity
[Description]:
GAK inhibitor 49 is a potent, selective, ATP-competitive inhibitor of cyclin G-associated kinase (GAK, cell IC50=56 nM) with favourable NAK family selectivity (AAK1, STK16, BMP2K); shows binding to only GAK and RIPK2 in an unbiased MIB/MS experiment in cell lysate.
[References]
References 1. Asquith CRM, et al. ChemMedChem. 2018 Jan 8;13(1):48-66. 2. Pu SY, et al. J Med Chem. 2018 Jul 16. doi: 10.1021/acs.jmedchem.8b00613. View Related Products by Target Other Targets
Chemical & Physical Properties
[ Molecular Formula ]:
C20H22N2O5
[ Molecular Weight ]:
370.405
Safety Information
[ Hazard Codes ]:
Xi
Related Compounds
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