JH-XVI-178

Modify Date: 2024-01-19 20:04:11

JH-XVI-178 Structure
JH-XVI-178 structure
Common Name JH-XVI-178
CAS Number 2648453-53-4 Molecular Weight 435.91
Density N/A Boiling Point N/A
Molecular Formula C22H22ClN7O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of JH-XVI-178


JH-XVI-178 is a highly potent and selective inhibitor of CDK8/19 that displays low clearance and moderate oral pharmacokinetic properties.

 Names

Name JH-XVI-178

 JH-XVI-178 Biological Activity

Description JH-XVI-178 is a highly potent and selective inhibitor of CDK8/19 that displays low clearance and moderate oral pharmacokinetic properties.
Related Catalog
Target

CDK8:1 nM (IC50)

CDK19:2 nM (IC50)

References

[1]. Hatcher JM, et al. Development of Highly Potent and Selective Pyrazolopyridine Inhibitor of CDK8/19. ACS Med Chem Lett. 2021 Oct 22;12(11):1689-1693.

 Chemical & Physical Properties

Molecular Formula C22H22ClN7O
Molecular Weight 435.91