2209084-73-9
2209084-73-9 structure
- Name: JH-VIII-49
- Chemical Name: JH-VIII-49
- CAS Number: 2209084-73-9
- Molecular Formula: C30H40N2
- Molecular Weight: 428.664
- Create Date: 2020-01-11 19:47:50
- Modify Date: 2023-01-22 13:54:41
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JH-VIII-49 is a potent and selective inhibitor of CDK8 with IC50 of 16 nM, also inhibits CDK19 (IC50=8 nM); displays excellent selectivity against a panel of 468 kinases at a concentration of 10 uM, only 4 has >90% inhibition; induces a dose-dependent inhibition of S727-STAT1 phosphorylation in HepG2 cells (at 5 uM).
| Name | JH-VIII-49 |
|---|
| Description | JH-VIII-49 is a potent and selective inhibitor of CDK8 with IC50 of 16 nM, also inhibits CDK19 (IC50=8 nM); displays excellent selectivity against a panel of 468 kinases at a concentration of 10 uM, only 4 has >90% inhibition; induces a dose-dependent inhibition of S727-STAT1 phosphorylation in HepG2 cells (at 5 uM). |
|---|---|
| References | References 1. John M. Hatcher, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.8b00011 View Related Products by Target Cyclin-dependent Kinase (CDK) |
| Molecular Formula | C30H40N2 |
|---|---|
| Molecular Weight | 428.664 |