2426628-52-4

2426628-52-4 structure

Name: JH-XIV-68-3
Chemical Name: JH-XIV-68-3
CAS Number: 2426628-52-4
Molecular Formula: C₂₁H₁₇F₃N₈O
Molecular Weight: 454.41
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK DYRK
Create Date: 2022-05-24 17:31:00
Modify Date: 2025-08-27 03:15:03
JH-XIV-68-3 is a selective macrocyclic inhibitor of DYRK1A/B. JH-XIV-68-3 displays selectivity for DYRK1A and close family member DYRK1B in biochemical and cellular assays. JH-XIV-68-3 demonstrates antitumor efficacy in head and neck squamous cell carcinoma (HNSCC) cell lines[1].

Name	JH-XIV-68-3

Description	JH-XIV-68-3 is a selective macrocyclic inhibitor of DYRK1A/B. JH-XIV-68-3 displays selectivity for DYRK1A and close family member DYRK1B in biochemical and cellular assays. JH-XIV-68-3 demonstrates antitumor efficacy in head and neck squamous cell carcinoma (HNSCC) cell lines[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK
References	[1]. Powell CE, et al. Selective Macrocyclic Inhibitors of DYRK1A/B. ACS Med Chem Lett. 2022;13(4):577-585.

Molecular Formula	C₂₁H₁₇F₃N₈O
Molecular Weight	454.41