2227368-54-7
2227368-54-7 structure
- Name: JH-X-119-01
- Chemical Name: JH-X-119-01
- CAS Number: 2227368-54-7
- Molecular Formula: C25H20N6O3
- Molecular Weight: 452.474
- Catalog: Signaling Pathways Immunology/Inflammation IRAK
- Create Date: 2022-02-06 12:49:12
- Modify Date: 2024-04-05 18:44:23
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Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 irreversibly labels IRAK1 at C302. This compound exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88. Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems.
| Name | JH-X-119-01 |
|---|
| Description | Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 irreversibly labels IRAK1 at C302. This compound exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88. Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems. |
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| Molecular Formula | C25H20N6O3 |
|---|---|
| Molecular Weight | 452.474 |
| Storage condition | 2-8℃ |