JH-X-119-01
Modify Date: 2025-08-27 19:44:05
JH-X-119-01 structure
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Common Name | JH-X-119-01 | ||
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| CAS Number | 2227368-54-7 | Molecular Weight | 452.474 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H20N6O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JH-X-119-01Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 irreversibly labels IRAK1 at C302. This compound exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88. Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems. |
| Name | JH-X-119-01 |
|---|
| Description | Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 irreversibly labels IRAK1 at C302. This compound exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88. Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems. |
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| Molecular Formula | C25H20N6O3 |
|---|---|
| Molecular Weight | 452.474 |
| InChIKey | WQVPGYMGERDXLH-UHFFFAOYSA-N |
| SMILES | C=CC(=O)Nc1cccc(C(=O)Nc2ccc(NC(=O)c3cccc(-c4ccn[nH]4)n3)cc2)c1 |
| Storage condition | 2-8℃ |