JH-X-119-01
Names
[ CAS No. ]:
2227368-54-7
[ Name ]:
JH-X-119-01
Biological Activity
[Description]:
Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 irreversibly labels IRAK1 at C302. This compound exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88. Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems.
Chemical & Physical Properties
[ Molecular Formula ]:
C25H20N6O3
[ Molecular Weight ]:
452.474
[ Storage condition ]:
2-8℃