JH-VIII-49
Names
[ CAS No. ]:
2209084-73-9
[ Name ]:
JH-VIII-49
Biological Activity
[Description]:
JH-VIII-49 is a potent and selective inhibitor of CDK8 with IC50 of 16 nM, also inhibits CDK19 (IC50=8 nM); displays excellent selectivity against a panel of 468 kinases at a concentration of 10 uM, only 4 has >90% inhibition; induces a dose-dependent inhibition of S727-STAT1 phosphorylation in HepG2 cells (at 5 uM).
[References]
References 1. John M. Hatcher, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.8b00011 View Related Products by Target Cyclin-dependent Kinase (CDK)
Chemical & Physical Properties
[ Molecular Formula ]:
C30H40N2
[ Molecular Weight ]:
428.664