JH-XVI-178

Names

[ Name ]:
JH-XVI-178

Biological Activity

[Description]:

JH-XVI-178 is a highly potent and selective inhibitor of CDK8/19 that displays low clearance and moderate oral pharmacokinetic properties.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK8:1 nM (IC50)

CDK19:2 nM (IC50)

[References]

[1]. Hatcher JM, et al. Development of Highly Potent and Selective Pyrazolopyridine Inhibitor of CDK8/19. ACS Med Chem Lett. 2021 Oct 22;12(11):1689-1693.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₂ClN₇O

[ Molecular Weight ]:
435.91

Related Compounds

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