BTK-IN-22

Modify Date: 2024-04-09 00:26:58

BTK-IN-22 structure	Common Name	BTK-IN-22
	CAS Number	2573048-10-7	Molecular Weight	454.52
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₆N₆O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BTK-IN-22

BTK-IN-22 is a BTK inhibitor (IC50: 0.9 nM). BTK-IN-22 also inhibits BLX and BMX with IC50s of 1.4 and 1.2 nM respectively. BTK-IN-22 shows improved kinase selectivity compared to Ibrutinib (HY-10997)[1]

Name	BTK-IN-22

Description	BTK-IN-22 is a BTK inhibitor (IC50: 0.9 nM). BTK-IN-22 also inhibits BLX and BMX with IC50s of 1.4 and 1.2 nM respectively. BTK-IN-22 shows improved kinase selectivity compared to Ibrutinib (HY-10997)[1]
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk
In Vitro	BTK-IN-23 (Compound 2) 抑制 Jeko-1 细胞中 BTK 自磷酸化，IC50 值为 109 nM[1]. Western Blot Analysis[1] Cell Line: Jeko-1 cell Concentration: 0.01, 0.1, 1, 10 μM Incubation Time: 2 h Result: Inhibited BTK autophosphorylation.
References	[1]. Sean T. Toenjes, et al. Controlling Ibrutinib’s Conformations about Its Heterobiaryl Axis to Increase BTK Selectivity. ACS Med. Chem. Lett. 2023. https://doi.org/10.1021/acsmedchemlett.2c00523

Molecular Formula	C₂₆H₂₆N₆O₂
Molecular Weight	454.52